Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review

Yarahmadi, Amir; Azarpira, Negar; Mostafavi-Pour, Zohreh

doi:10.22088/IJMCM.BUMS.10.3.181

Volume 10, Issue 3 (Int J Mol Cell Med 2021) Int J Mol Cell Med 2021, 10(3): 181-188 | Back to browse issues page

‎ 10.22088/IJMCM.BUMS.10.3.181

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Yarahmadi A, Azarpira N, Mostafavi-Pour Z. Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review. Int J Mol Cell Med 2021; 10 (3) :181-188
URL: http://ijmcmed.org/article-1-1707-en.html

Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review

Amir Yarahmadi¹

, Negar Azarpira²

, Zohreh Mostafavi-Pour³

1- Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. , zmostafavipour88@yahoo.co.uk

Abstract: (4154 Views)

The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine-protein kinase that senses and combines various environmental signals to regulate the growth and homeostasis of human cells. This signaling pathway synchronizes many critical cellular processes and is involved in an increasing number of pathological conditions such as diabetes, cancer, obesity, and metabolic syndrome. Here, we review different complications of diabetes that are associated with mTOR complex 1 imbalance. We further discuss pharmacological approaches to treat diabetes complications linked to mTOR deregulation.

Keywords: Diabetes, complications, mTOR, mTOR complex 1, signaling

Full-Text [PDF 273 kb] (1668 Downloads)

Type of Study: Mini-review | Subject: Clinical Biochemistry
Received: 2021/07/24 | Accepted: 2021/11/15 | Published: 2022/01/10