Altered mRNA Expression of Fucosyltransferases and Fucosidase Predicts Prognosis in Human Oral Carcinoma

Mehta, Kruti; Patel, Kinjal; Pandya, Shashank; Patel, Prabhudas

doi:10.22088/IJMCM.BUMS.10.2.123

Volume 10, Issue 2 (Int J Mol Cell Med 2021) Int J Mol Cell Med 2021, 10(2): 123-132 | Back to browse issues page

‎ 10.22088/IJMCM.BUMS.10.2.123

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Mehta K, Patel K, Pandya S, Patel P. Altered mRNA Expression of Fucosyltransferases and Fucosidase Predicts Prognosis in Human Oral Carcinoma. Int J Mol Cell Med 2021; 10 (2) :123-132
URL: http://ijmcmed.org/article-1-1507-en.html

Altered mRNA Expression of Fucosyltransferases and Fucosidase Predicts Prognosis in Human Oral Carcinoma

Kruti Mehta¹

, Kinjal Patel¹

, Shashank Pandya²

, Prabhudas Patel³

1- Molecular Oncology Laboratory, Cancer Biology Department, The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, Gujarat, India.
2- Surgical Oncology Department, The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, Gujarat, India.
3- Molecular Oncology Laboratory, Cancer Biology Department, The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, Gujarat, India. , prabhudas_p@hotmail.com

Abstract: (4386 Views)

Aberrant protein glycosylation is known to be associated with the development of various cancers. Although fucosylation is essential for normal biological functions, alterations in fucosylation are strongly implicated in cancer and increasing metastatic potential. Altered fucosyltarnsferases (FUTs) and fucosidases are found to be involved in many types of malignancies. In this study, we examined the mRNA expressions of fucosidase (FUCA1) and FUTs (FUTs (FUT3, FUT4, FUT5, FUT6, FUT8) in human oral cancer tissues. All FUTs and FUCA1 were significantly (P ≤ 0.05) down-regulated in malignant tissues in comparison with their adjacent normal tissues. The relationship between the clinicopathological parameters and the expression of FUTs and FUCA1 revealed that higher mRNA levels of FUT4, FUT5, and FUT8 and lower levels of FUT3 were associated with progression of disease and lymph node metastasis in oral carcinoma indicating their role in oral cancer progression. Collectively, results suggest that elevated mRNA levels of FUT4, FUT5 and FUT8 may be used as worst prognostic indicators for oral carcinoma.

Keywords: Oral cancer, hallmarks of cancer, glycosylation, fucosylation, fucosyltransferases, fucosidase

Full-Text [PDF 470 kb] (1546 Downloads)

Type of Study: Original Article | Subject: Cancer
Received: 2020/11/18 | Accepted: 2021/05/28 | Published: 2021/05/30