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:: Volume 9, Issue 4 (Int J Mol Cell Med (In Press) 2020) ::
Int J Mol Cell Med 2020, 9(4): 0-0 Back to browse issues page
PD-1, TIM-3, and LAG-3 Expression in T Cells in a Patient with Recurrent Ossifying Fibroma: A Case Report
Alejandro García-Muñoz1, Nayeli Goreti Nieto-Velázquez2, Gabriela Damian-Morales2, Carlos Liceaga-Escalera1, Luis Alberto Montoya-Perez1, Madeleine Cruz-Vélez1, Pabel Antonio Gómez-Hernández3, Cynthia Trejo-Iriarte3, Rodolfo Pastelin-Palacios4, Mario Moreno-Eutimio 5
1- Maxillofacial Surgery Service, Hospital Juárez de México, Mexico City, Mexico.
2- Research División, Hospital Juárez de México, Mexico City, Mexico.
3- Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (FES-Iztacala UNAM), Estado de México, México.
4- Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, México.
5- Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (FES-Iztacala UNAM), Estado de México, México. , marioadan@inmunoquimica.com
Abstract:   (109 Views)

Central ossifying fibroma is a benign, slow-growing tumor of mesenchymal origin with a predilection for the mandibular premolar and molar areas. The immunophenotype of T cells involved in the antitumor response against this benign tumor is unknown. In this case report, we described a case of a 48-year-old woman presenting with a very large recurrent ossifying fibroma in the mandible, which was successfully treated with hemimaxillectomy. In addition, we evaluated the expression of programmed cell death 1 receptor (PD-1), lymphocyte activation gene-3 (LAG-3), T cell immunoglobulin and mucin-domain containing-3 (TIM-3), cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), CD69 (activation inducer molecule) and CD25 (α chain of the high-affinity IL-2 receptor) in T cell populations from the tumor and peripheral blood of this uncommon lesion. The patient presented recurrent ossifying fibroma, and the tumor-infiltrating and peripheral blood T cells showed expression of PD-1, LAG-3, and TIM-3, suggesting an exhausted T cell response.

Keywords: Immune checkpoint proteins, ossifying fibroma, programmed cell death 1 receptor, T-lymphocytes
Full-Text [PDF 461 kb]   (34 Downloads)    
Type of Study: Case Report | Subject: Cancer
Received: 2020/08/2 | Accepted: 2020/11/15 | Published: 2020/11/30
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García-Muñoz A, Nieto-Velázquez N G, Damian-Morales G, Liceaga-Escalera C, Montoya-Perez L A, Cruz-Vélez M, et al . PD-1, TIM-3, and LAG-3 Expression in T Cells in a Patient with Recurrent Ossifying Fibroma: A Case Report. Int J Mol Cell Med. 2020; 9 (4)
URL: http://ijmcmed.org/article-1-1403-en.html


Volume 9, Issue 4 (Int J Mol Cell Med (In Press) 2020) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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