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:: Volume 8, Issue 2 (Int J Mol Cell Med [In press] 2019) ::
Int J Mol Cell Med 2019, 8(2): 0-0 Back to browse issues page
Investigating the Relationship between Magnesium levels and Diabetes Mellitus in Pregnant Women
Hadis Musavi1 , Fariba Mohamadi Tahroodi2 , Farzaneh Fesahat3 , Zinatossadat Bouzari 4, Seddigheh Esmailzadeh5 , Fatemeh Elmi1 , Shahla Yazdani6, Zoleika Moazezi7
1- Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
2- Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
3- Reproductive Immunology Research Center, Shahid Sadoghi University of Medical Sciences, Yazd, Iran.
4- Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. , Z_b412003@yahoo.com
5- Department of Obstetrics and Gynecology, School of Medicine, Infertility and Reproductive Health Research Center Fatima Al-Zahra Research Center for Fertility and Infertility, Babol University of Medical Sciences, Babol, Iran.
6- Clinical Research Development Unit of Rouhani Hospital, Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran.
7- Department of Endocrinology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol,. Iran.
Abstract:   (251 Views)
Gestational diabetes mellitus (GDM) is defined as one of the three main types of diabetes mellitus (DM). It is established that GDM is associated with exceeding nutrient losses owing to glycosuria. Magnesium (Mg), as one of the essential micronutrients for fetus development, acts as the main cofactor in most enzymatic processes. The aim of this study was to measure serum and cellular levels of Mg, albumin, creatinine, and total protein to further clarify the relationship between these components and DM in pregnant women. Blood samples were obtained from 387 pregnant women. The participants were classified into four groups based on their type of diabetes, namely GDM (n=96), DM (n=44), at high-risk of DM (n=122), and healthy controls (n=125). All participants' fasting blood sugar (FBS), creatinine, albumin, Mg, and total protein in the serum levels and red blood cell Mg (RBC-Mg) were measured during 24-28 weeks of gestation. Groups were compared for a possible association between DM and abortion, gravidity, and parity. The serum levels of creatinine, FBS, albumin, Mg, and RBC-Mg were statistically different among the four groups (P = 0.001). Significant lower levels of RBC-Mg was observed in all studied groups in comparison with controls. Given a positive correlation between DM and abortion, it seems that decreased levels of RBC-Mg and serum albumin can increase the risk of abortion in pregnant women. Our data demonstrated significant alterations in albumin, Mg, and creatinine concentrations in women with DM or those at high risk of DM during their gestational age. It seems that the measurement of these biochemical parameters might be helpful for preventing the complications, and improving pregnancies outcomes complicated with DM.
Keywords: Gestational diabetes mellitus, Magnesium serum, Albumin, Diabetes mellitus, Pregnancy
     
Type of Study: Original Article | Subject: Clinical Biochemistry
Received: 2019/05/10 | Accepted: 2019/09/10
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Musavi H, Mohamadi Tahroodi F, Fesahat F, Bouzari Z, Esmailzadeh S, Elmi F, et al . Investigating the Relationship between Magnesium levels and Diabetes Mellitus in Pregnant Women. Int J Mol Cell Med. 2019; 8 (2)
URL: http://ijmcmed.org/article-1-1086-en.html


Volume 8, Issue 2 (Int J Mol Cell Med [In press] 2019) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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