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:: Volume 2, Issue 4 (Int J Mol Cell Med 2013) ::
Int J Mol Cell Med 2013, 2(4): 194-198 Back to browse issues page
Comparative Study of Expression of Smad3 in Oral Lichen Planus and Normal Oral Mucosa
Shima Nafarzadeh1 , Samad Ejtehadi2 , Pouyan Amini Shakib 3, Majid Fereidooni4 , Ali Bijani5
1- Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran.
2- Private Dentist, Babol, Iran.
3- Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran. , pouyanshakib@yahoo.com
4- Department of Periodontology, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran.
5- Non-Communicable Pediatric Diseases Research Center, Amirkola Hospital, Babol University of Medical Sciences, Babol, Iran.
Abstract:   (11470 Views)
Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa which is considered by the World Health Organization (WHO) as a premalignant condition. One step in malignant development is so called epithelial mesenchymal transition (EMT), a process whereby epithelial cells acquire mesenchymal characteristics. A factor known to induce EMT is the transforming growth factor-β (TGF-β), which uses the Smad proteins as mediators for its signaling. The aim of this study was to compare the expression of Smad 3 in Oral Lichen Planus and normal oral mucosa. This descriptive analytic study was performed on 30 patients with OLP (21 women and 9 men with mean age of 45.23± 2.44 years) and 20 normal oral mucosa (14 women and 6 men with mean age of 46.95± 2.21 years). The samples were studied by immunohistochemical staining. Data were analyzed with paired T-test and Wilcoxon test by SPSS software. Expression of Smad3 in OLP samples and normal oral mucosa was different. This difference was statistically significant (P<0.001). The apparently higher expression of Smad 3 in oral lichen planus compared to normal oral mucosa might help to discuss its higher potential for malignant transition.
Keywords: Oral lichen planus, smad 3, transforming growth factor β
Full-Text [PDF 243 kb]   (3069 Downloads)    
Type of Study: Original Article | Subject: Histopathology
Received: 2013/09/23 | Accepted: 2013/11/24 | Published: 2013/11/24
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Nafarzadeh S, Ejtehadi S, Amini Shakib P, Fereidooni M, Bijani A. Comparative Study of Expression of Smad3 in Oral Lichen Planus and Normal Oral Mucosa. Int J Mol Cell Med 2013; 2 (4) :194-198
URL: http://ijmcmed.org/article-1-108-en.html


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Volume 2, Issue 4 (Int J Mol Cell Med 2013) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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