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:: Volume 2, Issue 4 (Int J Mol Cell Med 2013) ::
Int J Mol Cell Med 2013, 2(4): 194-198 Back to browse issues page
Comparative Study of Expression of Smad3 in Oral Lichen Planus and Normal Oral Mucosa
Shima Nafarzadeh1, Samad Ejtehadi2, Pouyan Amini Shakib 3, Majid Fereidooni4, Ali Bijani5
1- Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran.
2- Private Dentist, Babol, Iran.
3- Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran. , pouyanshakib@yahoo.com
4- Department of Periodontology, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran.
5- Non-Communicable Pediatric Diseases Research Center, Amirkola Hospital, Babol University of Medical Sciences, Babol, Iran.
Abstract:   (8015 Views)
Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa which is considered by the World Health Organization (WHO) as a premalignant condition. One step in malignant development is so called epithelial mesenchymal transition (EMT), a process whereby epithelial cells acquire mesenchymal characteristics. A factor known to induce EMT is the transforming growth factor-β (TGF-β), which uses the Smad proteins as mediators for its signaling. The aim of this study was to compare the expression of Smad 3 in Oral Lichen Planus and normal oral mucosa. This descriptive analytic study was performed on 30 patients with OLP (21 women and 9 men with mean age of 45.23± 2.44 years) and 20 normal oral mucosa (14 women and 6 men with mean age of 46.95± 2.21 years). The samples were studied by immunohistochemical staining. Data were analyzed with paired T-test and Wilcoxon test by SPSS software. Expression of Smad3 in OLP samples and normal oral mucosa was different. This difference was statistically significant (P<0.001). The apparently higher expression of Smad 3 in oral lichen planus compared to normal oral mucosa might help to discuss its higher potential for malignant transition.
Keywords: Oral lichen planus, smad 3, transforming growth factor β
Full-Text [PDF 243 kb]   (1719 Downloads)    
Type of Study: Original Article | Subject: Histopathology
Received: 2013/09/23 | Accepted: 2013/11/24 | Published: 2013/11/24
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Nafarzadeh S, Ejtehadi S, Amini Shakib P, Fereidooni M, Bijani A. Comparative Study of Expression of Smad3 in Oral Lichen Planus and Normal Oral Mucosa. Int J Mol Cell Med. 2013; 2 (4) :194-198
URL: http://ijmcmed.org/article-1-108-en.html


Volume 2, Issue 4 (Int J Mol Cell Med 2013) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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