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Int J Mol Cell Med 2019, 8 - Suppl 1_Int J Mol Cell Med: 56-62 Back to browse issues page
Association Analysis of the Common Genetic Variants of HNF4A Gene with Type 2 Diabetes Mellitus Risk
Seyedeh Mina Azizi1, Negar Sarhangi2 , Mahdi Afshari3 , Davood Abbasi4, Hamid Reza Aghaei Meybodi2 , Mandana Hasanzad 5
1- Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
2- Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran, Iran.
3- Department of Community Medicine, Zabol University of Medical Sciences, Zabol, Iran.
4- Iranian Diabetes Society, Eslamshahr Branch, Iran.
5- Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran, Iran. , mandanahasanzad@yahoo.com
Abstract:   (285 Views)
Type 2 diabetes mellitus (T2DM) is a complex disease that involves a wide range of genetic and environmental factors. The hepatocyte nuclear factor (HNF4A) carries out hepatic gluconeogenesis regulation and insulin secretion crucially, and the corresponding gene was shown to be linked to T2DM in several studies. The aim of the present study was to evaluate the association between HNF4A genetic variants (rs1884613 and rs1884614) and T2DM risk in a group of Iranian patients. This case-control study included 100 patients with T2DM and 100 control subjects. Genotyping of two single nucleotide polymorphisms (SNPs) (rs1884613 and rs1884614) of HNF4A was performed using the sequencing method. There was no statistically significant difference for allele and genotype distribution of the HNF4A common variants (rs1884613 and rs1884614) between subjects with and without T2DM (P=0.9 and P=0.9, respectively). Regarding diabetic complications, although the presence of mentioned polymorphisms increased the odds of developing ophthalmic complications and reduction of the odds of renal complications among diabetic patients, the mentioned risk was non- significant and cannot be generalized to the whole population.  It seems that rs1884613 and rs1884614 polymorphisms are not associated with T2DM or its renal and ophthalmic complications. To investigate the precise influence of these polymorphisms, prospective cohorts with larger sample sizes are required.
Keywords: T2DM, T2DM complication, HNF4A, Gene, Sequencing
Full-Text [PDF 679 kb]   (37 Downloads)    
Type of Study: Original Article | Subject: Genetics & Disease
Received: 2019/03/13 | Accepted: 2019/10/26 | Published: 2019/12/4
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Azizi S M, Sarhangi N, Afshari M, Abbasi D, Aghaei Meybodi H R, Hasanzad M. Association Analysis of the Common Genetic Variants of HNF4A Gene with Type 2 Diabetes Mellitus Risk. Int J Mol Cell Med. 2019; 8 (S1) :56-62
URL: http://ijmcmed.org/article-1-1041-en.html


Volume 8 - Suppl 1_Int J Mol Cell Med Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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