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Association between CYP19A <G rs700518 Polymorphism with Acne Vulgaris and its Severity: Influence on Sex Hormones Level
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Ali Ebrahimi1   , Zohreh Rahimi  2, Zomorod Ghadami1 , Ebrahim Shakiba3 , Ziba Rahimi1 , Mona Akbari1 , Mehrangiz Shafie3 , Fariborz Bahrehmand1 , Asad Vaisi-Raygani4 , Rozita Naseri5 |
1- Department of Dermatology, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2- Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. , zrahimi@kums.ac.ir
3- Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
4- Fertility and Infertility Research Center, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran.
5- Department of Internal Medicine, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran. |
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Abstract: (5202 Views) |
Acne vulgaris (AV) is a common skin disease that causes physical and psychological problems for affected individual. In addition to systemic changes in hormone levels, overproduction of local steroids, especially androgens are associated with AV. Cytochrome (CYP) 19 is involved in the synthesis of estrogens. The aim of the present study was to investigate the influence of CYP19A. |
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| Keywords: Acne vulgaris, CYP19, estradiol, SHBG, androgens |
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Full-Text [PDF 346 kb]
(2123 Downloads)
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Type of Study: Original Article |
Subject:
Genetics & Disease
Received: 2019/01/18 | Accepted: 2019/07/19 | Published: 2020/02/5
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