:: Volume 6, Issue 3 (Int J Mol Cell Med 2017) ::
Int J Mol Cell Med 2017, 6(3): 174-182 Back to browse issues page
Local Allergic Rhinitis in Pediatric Patients: is IgE Dosage in Nasal Lavage Fluid a Usefull Diagnostic Method in Children?
Laura Colavita 1, Natalia Catalano2, Giovanna Sposito3, Saverio Loddo3, Bruno Galletti2, Carmelo Salpietro4, Francesco Galletti2, Caterina Cuppari4
1- Department of Pediatrics, Hospital “Umberto I°” of Siracusa, Siracusa, Italy. , lauracol85@gmail.com
2- Department of Otolaryngology, University Hospital of Messina, Messina, Italy.
3- Department of Laboratory Diagnostics, Unit of Clinical Pathology, University Hospital of Messina, Messina, Italy.
4- Department of Adult and Childhood Human Pathology, Unit of Genetics and Pediatric Immunology, University Hospital of Messina, Messina, Italy.
Abstract:   (2519 Views)

Local Allergic Rhinitis (LAR) is an emerging disease. However, its incidence in the pediatric population has not yet been studied. The gold-standard for the diagnosis is the nasal provocation test that is not everywhere available and difficult to apply in children. The aim of our study is to evaluate the nasal lavage fluid IgE as a biomarker of LAR in children. 54 pediatric patients [IQR 4.0-12.0 years] were divided into 3 groups: study group (26 children with rhinitis symptoms and without evidence of systemic atopy); allergic rhinitis (AR) group (15 children) and 13 healthy controls (HC). Every child was subjected to nasal lavage using 2 ml/nostril of the physiologic saline solution, that was therefore analyzed by ImmunoCAP to obtain the IgE concentration. Rhinofibroscopy and nasal cytology were performed. Our data show the presence of higher value of nasal lavage fluid IgE (average of 6.005 UI/ml; range: 4.47-7.74 UI/ml) in 16 out of 26 patients of the study group who therefore may be classified as affected by LAR. We observed a statistically significant difference (P< 0.0001) between NAR/HC group and LAR group, identifying a cut-off of 3.85 UI/ml. Finally, we found a better response to previous AR therapy in the LAR group than in the NAR group. Our data show the high incidence of LAR in pediatric patients previously classified as NAR. The measurement of IgE in nasal lavage fluid may be considered an easy and rapid method for the diagnosis of LAR in children. Besides, our data adds confirmatory evidences about the good response of LAR children to the classic AR therapy.

Keywords: Local allergic rhinitis, nasal lavage fluid, IgE, children, non-allergic rhinitis with eosinophilia syndrome (NARES)
Full-Text [PDF 366 kb]   (896 Downloads)    
Type of Study: Original Article | Subject: Biomarkers (diagnosis & treatment)
Received: 2017/06/26 | Accepted: 2017/09/25 | Published: 2017/09/26

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Volume 6, Issue 3 (Int J Mol Cell Med 2017) Back to browse issues page