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Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review
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: (3287 مشاهده) |
| The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine-protein kinase that senses and combines various environmental signals to regulate the growth and homeostasis of human cells. This signaling pathway synchronizes many critical cellular processes and is involved in an increasing number of pathological conditions such as diabetes, cancer, obesity, and metabolic syndrome. Here, we review different complications of diabetes that are associated with mTOR complex 1 imbalance. We further discuss pharmacological approaches to treat diabetes complications linked to mTOR deregulation. |
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متن کامل [PDF 273 kb]
(1219 دریافت)
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نوع مطالعه: Mini-review |
موضوع مقاله:
Clinical Biochemistry
دریافت: 1400/5/2 | پذیرش: 1400/8/24 | انتشار: 1400/10/20
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