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:: Volume 12, Issue 1 (Int J Mol Cell Med 2023) ::
Int J Mol Cell Med 2023, 12(1): 1-17 Back to browse issues page
P19 a Parthenin Analog Induces Cell Lineage Dependent Apoptotic and Immunomodulatory Signaling in Acute Lymphoid Leukemia Cells
Vishal Sharma1 , Samriti Dhawan2 , Ajay Kumar3 , Jageep Kaur 4
1- Department of Biotechnology, Panjab University, Chandigarh, India.
2- Department of Biotechnology, Goswami Ganesh Dutta Sanatan Dharma College, Chandigarh, India.
3- Pharmacology Division, Indian Institute of Integrative Medicine, Jammu, India.
4- Department of Biotechnology, Panjab University, Chandigarh, India. , sharmavishal_biotechs@yahoo.com
Abstract:   (578 Views)
Leukemia is a type of cancer that affects the blood and bone marrow. Acute lymphoid leukaemia, also known as ALL, is regarded as one of the deadliest forms of cancer. Due to the rapid increase in various cancer cases and the development of resistance in cancer cells, it is necessary to identify novel lead molecules with more potent anticancer properties. There is a growing interest in using herbal products/analogs as multi-component agents (as anticancer agents and immunomodulators) for cancer treatment. In the present investigation, an attempt has been made to explore the anticancer and immunomodulatory activity of P19, an analog of parthenin in ALL. P19 was reported to exhibit anticancer efficacy by triggering apoptotic signaling events in human leukaemia HL-60 cells by significant NO production. In contrast to this finding, ROS and NO were not required for P19-mediated apoptosis in Raji cells. The mechanism of action of P19 was observed to be cancer cell lineage dependent. P19 demonstrated very effective anticancer properties against ALL (IC50 3µM). Molecular investigations revealed that P19 induced mitochondrion mediated apoptosis by Bax localization to mitochondria and enhanced cytosolic calcium in the cytoplasm. Further activation of the caspase 3, caspase 8 and PARP cleavage suggested the involvement of the caspase-mediated apoptosis. Anti-proliferative activity revealed the telomerase inhibition and cell cycle arrest in G0/G1 phase after P19 treatment. Immunomodulatory effects of the P19 revealed the enhanced INFÉ£ and NO production in Jurkat and THP cells. Owing to its antiproliferative and immunomodulatory potential against leukemia cells P19 can further be explored as effective therapeutics against leukemia.

Keywords: Acute lymphoid leukemia, apoptosis, immunomodulation, anticancer, Raji cells
Full-Text [PDF 1110 kb]   (398 Downloads)    
Type of Study: Original Article | Subject: Cancer
Received: 2022/05/31 | Accepted: 2023/09/30 | Published: 2023/09/19
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Sharma V, Dhawan S, Kumar A, Kaur J. P19 a Parthenin Analog Induces Cell Lineage Dependent Apoptotic and Immunomodulatory Signaling in Acute Lymphoid Leukemia Cells. Int J Mol Cell Med 2023; 12 (1) :1-17
URL: http://ijmcmed.org/article-1-1933-en.html


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Volume 12, Issue 1 (Int J Mol Cell Med 2023) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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