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:: Volume 8, Issue 3 (Int J Mol Cell Med 2019) ::
Int J Mol Cell Med 2019, 8(3): 191-199 Back to browse issues page
Possible Anti-inflammatory Effects of Mesenchymal Stem Cells Transplantation via Changes in CXCL8 Levels in Patients with Refractory Rheumatoid Arthritis
Arezoo Gowhari shabgah1 , Zhaleh Shariati-Sarabi2 , Jalil Tavakkol-Afshari1 , Mohsen Ghoryani3 , Mojgan Mohammadi 4
1- Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Immunology Department, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Department of Laboratory Sciences, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran; Research Center of Advanced Technologies in Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
4- Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. , mohammadimzh@mums.ac.ir
Abstract:   (1211 Views)
The synovial-lining cells have been involved with rheumatoid arthritis (RA) through the secretion of various cytokines and chemokines. Increased levels of these cytokines and chemokines are seen first in the synovial and subsequently in the bloodstream of RA patients. The synovial and circulating levels of CXCL8, CXCL12, and CXCL13 are higher in the RA patients than in the healthy subjects, causing migration of immune cells to the joints, which is associated with increased joint destruction. We aimed to evaluate the effects of autologous mesenchymal stem cells intravenous administration on plasma levels of CXCL8, CXCL12 and CXCL13 at 1, 6, and 12 month follow-up periods in refractory RA patients. 13 patients with refractory RA received autologous mesenchymal stem cells (MSCs). The ELISA technique was used to evaluate the plasma level of these chemokines. CXCL8 levels were significantly decreased at month 6 after MSCs transplantation in comparison with pre-injection level, and the concentration of this chemokine was significantly increased at month 12 in comparison with the month 6 after injection (P < 0.05). The levels of CXCL12 and CXCL13 were insignificantly decreased at months 1 and 6 after the MSCs transplantation. The interaction of MSCs after migration to the inflamed joints with CXCL8-producing cells could be one but not the only possible mechanism that reduces its production in the joints and subsequently in the plasma of RA patients. CXCL8 reduction as a consequence of MSCs application returned to pre-injection levels after 12 months. Therefore, increasing the dose of MSCs and replication of injections may maintain the potential anti-inflammatory effects of MSCs on the production of CXCL8 as an inflammatory mediator in patients with refractory RA.
Keywords: Rheumatoid arthritis, mesenchymal stem cells transplantation, CXCL8, CXCL12, CXCL13
Full-Text [PDF 148 kb]   (214 Downloads)    
Type of Study: Original Article | Subject: Stem Cell
Received: 2019/11/9 | Accepted: 2020/01/2 | Published: 2020/04/26
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Gowhari shabgah A, Shariati-Sarabi Z, Tavakkol-Afshari J, Ghoryani M, Mohammadi M. Possible Anti-inflammatory Effects of Mesenchymal Stem Cells Transplantation via Changes in CXCL8 Levels in Patients with Refractory Rheumatoid Arthritis. Int J Mol Cell Med. 2019; 8 (3) :191-199
URL: http://ijmcmed.org/article-1-1200-en.html


Volume 8, Issue 3 (Int J Mol Cell Med 2019) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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