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:: Volume 8, Issue 4 (Int J Mol Cell Med 2019) ::
Int J Mol Cell Med 2019, 8(4): 247-257 Back to browse issues page
Association of MicroRNA-155 rs767649 polymorphism with Susceptibility to Preeclampsia
Shymaa E. Ayoub 1, Olfat G. Shaker2 , Mostafa Y. Abdelwahed3, Naglaa A. Ahmed3, Hazem G. Abdelhameed4, Almandouh H. Bosilah4, Sheren R. Mohammed5
1- Department of Biochemistry and Molecular Biology, Fayoum University, Al Fayoum, Egypt. , ssa05@fayoum.edu.eg
2- Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Giza, Egypt.
3- Department of Physiology, Faculty of Medicine, Zagazig University, ElZagazig, Egypt.
4- Department of Gynecology and Obstetrics, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt.
5- Department of Biochemistry and Molecular Biology, Fayoum University, Al Fayoum, Egypt.
Abstract:   (876 Views)
Preeclampsia (PE) is a multifactorial disorder. Several studies showed that micro RNAs may play a critical role in PE pathogenesis. We aimed to investigate for the first time the association of mir-155rs767649 polymorphism with PE. Eighty patients with preeclampsia and 80 normal subjects were enrolled in the study. Serum expression levels of mature mir-155were evaluated using real-time PCR, and mir-155 rs767649 (T/A) polymorphism was genotyped using TaqMan SNP genotyping. There was a significant difference between the expression level of mir-155 in cases (5.86 ± 3.11) in comparison with controls (0.58 ± 0.30) (P<0.0001). Also,the minor allele of rs767649 was significantly associated with increased risk of PE [Recessive model: adjusted Odds ratio (OR) = 5.240, 95% confidence interval (CI) = (1.999-13.733),P= 0.001]. There was a significant difference between different genotypes according to expression levels of mir-155 in PE (P<0.0001) with high expression levels in TA genotype (7.10 ± 3.11 ). Mir-155 may play a critical role in PE pathogenesis. The obtained data suggest that a minor allele of rs767649 might be a predisposing factor for PE.
Keywords: MicroRNA, mir-155, single nucleotidepolymorphism, preeclampsia
Full-Text [PDF 134 kb]   (223 Downloads)    
Type of Study: Original Article | Subject: Biomarkers (diagnosis & treatment)
Received: 2019/09/30 | Accepted: 2020/04/9 | Published: 2020/05/29
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E. Ayoub S, G. Shaker O, Y. Abdelwahed M, A. Ahmed N, G. Abdelhameed H, H. Bosilah A et al . Association of MicroRNA-155 rs767649 polymorphism with Susceptibility to Preeclampsia. Int J Mol Cell Med. 2019; 8 (4) :247-257
URL: http://ijmcmed.org/article-1-1171-en.html


Volume 8, Issue 4 (Int J Mol Cell Med 2019) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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