دوره 13، شماره 4 - ( 7-1403 )                   | برگشت به فهرست نسخه ها


XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Chizhikova G, Khotin M, Bildyug N. Enhancing the Cardiogenic Potential of Human Mesenchymal Stem Cells via Extracellular Matrix Proteins. Int J Mol Cell Med 2024; 13 (4) :337-349
URL: http://ijmcmed.org/article-1-2422-fa.html
Enhancing the Cardiogenic Potential of Human Mesenchymal Stem Cells via Extracellular Matrix Proteins. مجله بین المللی سلولی و مولکولی. 1403; 13 (4) :337-349

URL: http://ijmcmed.org/article-1-2422-fa.html


:   (717 مشاهده)
Current in vitro models of cardiogenic differentiation include a variety of manipulations and stimulating agents, which interfere with the application of such models for preclinical drug testing. So, the aim of this study was to develop an approach for cardiogenic differentiation in vitro with a minimum of manipulations and to assess the influence of the extracellular matrix protein collagen IV on the cardiogenic potential of human mesenchymal stem cells (MSCs). Cardiogenic markers were analyzed by immunofluorescence staining and Western blot analysis. The results showed that collagen IV increased the cardiac marker GATA4 and altered the level of muscle actin isoforms, α-smooth muscle actin and α-cardiac muscle actin, in two different lines of human MSCs. The results indicate that the use of matrices containing collagen IV may increase the cardiogenic potential of human MSCs and may be a promising approach to obtain an in vitro model for cardiogenic differentiation suitable for preclinical drug discovery.
متن کامل [PDF 686 kb]   (384 دریافت)    
نوع مطالعه: Original Article | موضوع مقاله: Cell Biology
دریافت: 1403/6/8 | پذیرش: 1403/8/6 | انتشار: 1403/9/10

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به International Journal of Molecular and Cellular Medicine IJMCM می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2025 CC BY-NC 4.0 | International Journal of Molecular and Cellular Medicine IJMCM

Designed & Developed by : Yektaweb