[صفحه اصلی ]   [Archive]  
:: صفحه اصلي :: درباره نشريه :: آخرين شماره :: تمام شماره‌ها :: جستجو :: ثبت نام :: ارسال مقاله :: تماس با ما ::
بخش‌های اصلی
صفحه اصلی::
اطلاعات نشریه::
آرشیو مجله و مقالات::
برای نویسندگان::
برای داوران::
ثبت نام و اشتراک::
تماس با ما::
::
جستجو در پایگاه

جستجوی پیشرفته
..
دریافت اطلاعات پایگاه
نشانی پست الکترونیک خود را برای دریافت اطلاعات و اخبار پایگاه، در کادر زیر وارد کنید.
..
:: دوره 7، شماره 1 - ( 11-1396 ) ::
برگشت به فهرست نسخه ها
Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease
:   (7768 مشاهده)
Animal cells possess thousands of long non-coding (lnc) RNAs, such as antisense noncoding RNA in the INK4 locus (ANRIL) , which have regulatory roles in the cells’ molecular mechanisms, including X-chromosome inactivation, and developmental processes.  These lnc RNAs are known to influence the extensive spectrum of age-related disorders. Accordingly, there is evidence for the role of these lnc RNAs in cardiovascular diseases, particularly coronary artery diseases (CAD). The aim of this study was to assess whether the expression of the lnc RNA ANRIL was associated with a susceptibility to CAD by evaluating the expression level of the two transcripts of ANRIL. Peripheral blood was taken from fifty patients affected by CAD and relative expression of ANRIL was  determined by Real-Time PCR assay. The obtained data indicated that the EU741058 transcript expression level was significantly decreased in CAD patients in comparison with the healthy individuals (P= 0.001). Furthermore, there was no significant association between the NR_003529 transcript expression, and CAD risk in Iranian patients (P= 0.751). Our results suggest that the expression level of the EU741058 transcript of ANRIL may be implicated in CAD development, creating a predictive biomarker for CAD patients in future.
متن کامل [PDF 401 kb]   (2116 دریافت)    
نوع مطالعه: Original Article | موضوع مقاله: Genetics & Disease
دریافت: 1396/6/24 | پذیرش: 1396/10/16 | انتشار: 1396/11/21
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA



XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Yari M, Bitarafan S, Broumand M A, Fazeli Z, Rahimi M, Ghaderian S M H, et al . Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease. Int J Mol Cell Med 2018; 7 (1) :1-7
URL: http://ijmcmed.org/article-1-739-fa.html

Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease. مجله بین المللی سلولی و مولکولی. 1396; 7 (1) :1-7

URL: http://ijmcmed.org/article-1-739-fa.html



بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
دوره 7، شماره 1 - ( 11-1396 ) برگشت به فهرست نسخه ها
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
Persian site map - English site map - Created in 0.06 seconds with 37 queries by YEKTAWEB 4645