:: Volume 7, Issue 2 (Int J Mol Cell Med 2018) ::
Int J Mol Cell Med 2018, 7(2): 69-79 Back to browse issues page
Derived Mesenchymal Stem Cells in Addiction Related Hippocampal Damages
Raheleh Rafaiee1, Naghmeh Ahmadiankia 2
1- Addiction Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.
2- School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. , Ahmadian@shmu.ac.ir
Abstract:   (2287 Views)
The brain is an important organ that controls all sensory and motor actions, memory, and emotions. Each anatomical and physiological modulation in various brain centers, results in psychological, behavioral, and sensory-motor changes. Alcohol and addictive drugs such as opioids and amphetamines have been shown to exert a great impact on brain, specifically on the hippocampus. Emerging evidence has indicated that altered hippocampal neurogenesis is associated with the pathophysiology of neuropsychological disorders including addiction. The addictive drugs impair neurogenesis and undermine the function of neural stem/progenitor cells in hippocampus. This feature was claimed to be one of the underlying mechanisms of behavioral changes in patients with addiction. As the impairment of stem cells’ function has been proved to be the underlying cause of pathologic neuroadaptations in the brain, the administration of stem cell populations has shown promising results for re-modulating of neuronal status in the brain and especially in the hippocampus. Among different types of stem cells, bone marrow derived mesenchymal stem cells are the most proper candidates for stem cell therapies. In this review article, the recent studies on the effects of addictive drugs on brain neurogenesis, and also the promising potential effects of stem cells in curing addiction related hippocampal damages are discussed.
Keywords: addiction, hippocampus, neurogenesis, neural stem/progenitor cells, mesenchymal stem cells
Full-Text [PDF 226 kb]   (468 Downloads)    
Type of Study: Review | Subject: Neurosciences
Received: 2018/03/16 | Accepted: 2018/06/13 | Published: 2018/06/20

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Volume 7, Issue 2 (Int J Mol Cell Med 2018) Back to browse issues page