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Fetal Vegf Genotype is More Important for Abortion Risk than Mother Genotype
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Sinem Yalcintepe1   , Fatma Silan1 , Servet Hacivelioglu2 , Ahmet Uludag1 , Emine Cosar2 , Ozturk Ozdemir 3 |
1- Department of Medical Genetics, School of Medicine, Canakkale On Sekiz Mart University
2- Department of Gynecology and Obstetrics, School of Medicine, Canakkale On Sekiz Mart University
3- Department of Medical Genetics, School of Medicine, Canakkale On Sekiz Mart University , ozdemir615@yahoo.com |
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Abstract: (12728 Views) |
| Background
VEGF gene has been reported to be related with many diseases and recurrent pregnancy loss in various studies. VEGF polymorphisms are risk factors for pregnancy losses, and generally studies report only women’s genetic analyses. To evaluate the association between VEGF A C405G, C460T, C936T and C2578A polymorphisms and spontaneous abortion, we studied the genotypes of spontaneously aborted fetuses, their mothers and healthy control cases.
Methods
23 spontaneously aborted fetal materials, 22 mothers who had these abortions and 86 healthy control cases included to this study. VEGF A C405G, C460T, C936T and C2578A polymorphisms are analysed by Real Time PCR technique after genomic DNA isolation from all samples.
Results
VEGF A +405GG genotype and +405G allele were higher in fetuses comparing both with mothers and healthy control group. VEGF A +936TT genotype and +936T allele were higher in fetuses comparing with mothers. VEGF A +460C/T polymorphism CT and TT genotypes were higher in fetuses comparing with mothers.
Conclusions
We ascertained that VEGF A +405C/G, +460C/T, and +936C/T polymorphisms are risk factors for spontaneous abortion in fetal genotypes comparing with their mothers and healthy control cases. |
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| Keywords: Spontaneous abortion, VEGF, Polymorphism, Fetus, SNP |
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Full-Text [PDF 77 kb]
(3424 Downloads)
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Type of Study: Original Article |
Subject:
Genetics & Disease
Received: 2014/04/7 | Accepted: 2014/04/27 | Published: 2014/05/25
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