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:: دوره 9، شماره 4 - ( 8-1399 ) ::
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PD-1, TIM-3, and LAG-3 Expression in T Cells in a Patient with Recurrent Ossifying Fibroma: A Case Report
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Central ossifying fibroma is a benign, slow-growing tumor of mesenchymal origin with a predilection for the mandibular premolar and molar areas. The immunophenotype of T cells involved in the antitumor response against this benign tumor is unknown. In this case report, we described a case of a 48-year-old woman presenting with a very large recurrent ossifying fibroma in the mandible, which was successfully treated with hemimaxillectomy. In addition, we evaluated the expression of programmed cell death 1 receptor (PD-1), lymphocyte activation gene-3 (LAG-3), T cell immunoglobulin and mucin-domain containing-3 (TIM-3), cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), CD69 (activation inducer molecule) and CD25 (α chain of the high-affinity IL-2 receptor) in T cell populations from the tumor and peripheral blood of this uncommon lesion. The patient presented recurrent ossifying fibroma, and the tumor-infiltrating and peripheral blood T cells showed expression of PD-1, LAG-3, and TIM-3, suggesting an exhausted T cell response.

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نوع مطالعه: Case Report | موضوع مقاله: Cancer
دریافت: 1399/5/12 | پذیرش: 1399/8/25 | انتشار: 1399/9/10
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García-Muñoz A, Nieto-Velázquez N G, Damian-Morales G, Liceaga-Escalera C, Montoya-Perez L A, Cruz-Vélez M, et al . PD-1, TIM-3, and LAG-3 Expression in T Cells in a Patient with Recurrent Ossifying Fibroma: A Case Report. Int J Mol Cell Med. 2020; 9 (4)
URL: http://ijmcmed.org/article-1-1403-fa.html

PD-1, TIM-3, and LAG-3 Expression in T Cells in a Patient with Recurrent Ossifying Fibroma: A Case Report. مجله بین المللی سلولی و مولکولی. 1399; 9 (4)

URL: http://ijmcmed.org/article-1-1403-fa.html



دوره 9، شماره 4 - ( 8-1399 ) برگشت به فهرست نسخه ها
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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