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:: دوره 9، شماره 1 - ( 2-1399 ) ::
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Saponins from Tribulusterrestris L. Extract Down-regulateExpression of ICAM-1, VCAM-1 and E-selectin in Human Endothelial Cell Lines
:   (139 مشاهده)
Atherosclerosis is an inflammatory disease in which intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin (SELE) are consistently expressed in the vascular endothelium. Several evidence support the crucial role of adhesion molecules in the development of atherosclerosis and plaque instability. Due to the anti-inflammatory activity of Tribulusterrestris (TT), the present study investigated the effect of aqueous extract and saponin fraction of TT on the expression of ICAM-1, VCAM-1, and SELE genes in endothelial cells during normal and lipopolysaccharide (LPS) induced conditions. Human umbilical vein endothelial cells (HUVEC) and human bone marrow endothelial cells (HBMEC) were cultured, stimulated by LPS, and treated with aqueous extract and saponin fraction of TT. Finally, the expression of ICAM-1, VCAM-1, and SELE genes were measured using real-time quantitative reverse transcription polymerase chain reaction. LPS-induced HUVECs and HBMECs significantly increased the expression of ICAM-1, VCAM-1, and SELE in comparison with control groups (P<0.001). Treatment of LPS-induced HUVECs and HBMECs by aqueous extract and saponin fraction of TT decreased the expression of all three mentioned genes significantly (P<0.001) in comparison with LPS-induced cells. Taken together, our data suggest that TT has an anti-inflammatory effect. Studying in vivo anti-inflammatory effect of this herb may provide new insights into the development of a herbal drug for the prevention/therapy of atherosclerosis.
     
نوع مطالعه: Original Article | موضوع مقاله: Other
دریافت: ۱۳۹۸/۱۱/۱۹ | پذیرش: ۱۳۹۹/۲/۲۱
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Fereydouni Z, Amirinezhad Fard E, Mansouri K, Mohammadi Motlagh H, Mostafaie A. Saponins from Tribulusterrestris L. Extract Down-regulateExpression of ICAM-1, VCAM-1 and E-selectin in Human Endothelial Cell Lines. Int J Mol Cell Med. 2020; 9 (1)
URL: http://ijmcmed.org/article-1-1255-fa.html

Saponins from Tribulusterrestris L. Extract Down-regulateExpression of ICAM-1, VCAM-1 and E-selectin in Human Endothelial Cell Lines. مجله بین المللی سلولی و مولکولی. 1399; 9 (1)

URL: http://ijmcmed.org/article-1-1255-fa.html



دوره 9، شماره 1 - ( 2-1399 ) برگشت به فهرست نسخه ها
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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