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:: دوره 6، شماره 1 - ( 10-1395 ) ::
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Evaluation of Placentalmir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia
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It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression.  This study was performed to determine whether PEis associated with alterations in placental non-codingRNAs expression. MicroRNA(miR)-155-5p and long non-coding RNA (lnc)sONE expression, in placentas collected sequentially from 59 patients with PE and 40 normotensive pregnancies were measured using real-time PCR.The relationship between miR-155-5p and lncsONE expressions wasanalyzed statistically. miR-155-5p expression was increased(fold change=1.6, P=0.04), whilelncsONE expression was not significantly changed(fold change=1.1, P=0.68), in placentas from patients compared with control group.miR-155-5p was upregulated in placentas from patients with PEand may have influencedeNOS expression. These findings indicate that miRNA-155-5p may be involved in PE pathogenesis and could be a potential biomarker for this disease.

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نوع مطالعه: Original Article | موضوع مقاله: Genetics & Disease
دریافت: ۱۳۹۵/۹/۱۶ | پذیرش: ۱۳۹۵/۱۰/۱۹ | انتشار: ۱۳۹۵/۱۰/۲۸
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Azizi F, Saleh Gargari S, Asadi Shahmirzadi S, Dodange F, Amiri V, Mirfakhraie R et al . Evaluation of Placentalmir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia. Int J Mol Cell Med. 2017; 6 (1) :22-30
URL: http://ijmcmed.org/article-1-628-fa.html

Evaluation of Placentalmir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia. مجله بین المللی سلولی و مولکولی. 1395; 6 (1) :22-30

URL: http://ijmcmed.org/article-1-628-fa.html



دوره 6، شماره 1 - ( 10-1395 ) برگشت به فهرست نسخه ها
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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