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Anti-CD19 Monoclonal Antibodies: a New Approach to Lymphoma Therapy
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CD19 is expressed on B- lineage cells and follicular dendritic cells and plays a key role in B cell malignancies and autoimmune diseases. Thus, it has been considered as potential target for several monoclonal antibodies (mAbs). For decades, chemotherapy has been known as one of the major antitumor therapies eradicating high proliferative tumor cells. But, anti- CD19 mAbs developed for treating CD19- positive lymphomas and autoimmune diseases would rank among the most novel area of research and development in the pharmaceutical industry. Moreover, several anti- CD19 mAbs are currently being tested in various clinical trials and this review provides an overview of the research accomplished so far.

متن کامل [PDF 159 kb]   (1941 دریافت)    
نوع مطالعه: Review | موضوع مقاله: Medical Pharmacology
دریافت: ۱۳۹۳/۱۲/۱۶ | پذیرش: ۱۳۹۴/۳/۴ | انتشار: ۱۳۹۴/۴/۳۰
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Naddafi F, Davami F. Anti-CD19 Monoclonal Antibodies: a New Approach to Lymphoma Therapy. Int J Mol Cell Med. 2015; 4 (3) :143-151
URL: http://ijmcmed.org/article-1-306-fa.html

Anti-CD19 Monoclonal Antibodies: a New Approach to Lymphoma Therapy. مجله بین المللی سلولی و مولکولی. 1394; 4 (3) :143-151

URL: http://ijmcmed.org/article-1-306-fa.html



دوره 4، شماره 3 - ( 4-1394 ) برگشت به فهرست نسخه ها
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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