International Journal of Molecular and Cellular Medicine (IJMCM)
Cellular and Molecular Biology Research Center, Babol University of Medical Sciences
جمعه 23 خرداد 1404
[Archive]
دوره 12، شماره 4 - ( 7-1402 )
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Ostovar T, Rezaei Arablouydareh S, Shokri-Afra H, Samavarchi Tehrani S, Namvarjah F, Aliabadi M, et al . Effect of Capparis spinosa Fruit Hydroalcoholic Extract on Paraquat-Induced Pulmonary Fibrosis in the Rat. Int J Mol Cell Med 2023; 12 (4) :423-434
URL: http://ijmcmed.org/article-1-2231-fa.html
URL: http://ijmcmed.org/article-1-2231-fa.html
Effect of Capparis spinosa Fruit Hydroalcoholic Extract on Paraquat-Induced Pulmonary Fibrosis in the Rat. مجله بین المللی سلولی و مولکولی. 1402; 12 (4) :423-434
: (853 مشاهده)
Pulmonary fibrosis (PF) is a lethal inflammatory disease and there has been no effective medication for this progressive disease up to now. Paraquat is commonly used in agricultural settings to control weed growth and is one of the important risk factors for PF. Additionally, emerging evidence has demonstrated Capparis spinosa (C. spinose) fruit extract has anti-fibrotic, anti-inflammatory, and antioxidant properties. We aimed to evaluate whether C. spinose fruit hydroalcoholic extract has a positive effect against Paraquat-induced PF in rats. 30 male Wistar rats were randomly divided into 5 groups, which included: a control group, a Paraquat control group, a C. spinose group with a dose of 20 mg/kg, a C. spinose group with a dose of 30 mg/kg, a C. spinose group with a dose of 50 mg/kg. After 21 days of the treatment, levels of hydroxyproline and malondialdehyde (MDA) in lung tissue were assessed and lung indices and semi-quantitative histopathological changes were determined. The results showed that treatment with C. spinose, led to increased weight gain, whereas reduced lung weight. C. spinose demonstrated a decreasing effect on levels of MDA, and hydroxyproline in lung tissue. Moreover, histopathological data and the number of lung indices indicated the preventive role of C. spinose Paraquat-induced PF in rats.
نوع مطالعه: Original Article |
موضوع مقاله:
Clinical Biochemistry
دریافت: 1402/8/3 | پذیرش: 1403/1/20 | انتشار: 1403/3/5
دریافت: 1402/8/3 | پذیرش: 1403/1/20 | انتشار: 1403/3/5
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