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Pourghasem M, Nasiri E, Shafi H. Early Renal Histological Changes in Alloxan-Induced Diabetic Rats. Int J Mol Cell Med 2014; 3 (1) :11-15
URL: http://ijmcmed.org/article-1-116-fa.html
Early Renal Histological Changes in Alloxan-Induced Diabetic Rats. مجله بین المللی سلولی و مولکولی. 1392; 3 (1) :11-15

URL: http://ijmcmed.org/article-1-116-fa.html

Early Renal Histological Changes in Alloxan-Induced Diabetic Rats
:   (9915 مشاهده)
Diabetes mellitus is a progressive disease. Most investigators have focused on glomerular changes in diabetic kidney and non-glomerular alterations have been less attended. The present study has been conducted to find early non-glomerular histological changes in diabetic renal tissue. Twenty male Wistar rats weighting 200-250 g were used for the diabetic group. Diabetes mellitus was induced by single injection of Alloxan. After 8 weeks, paraffin embedded blocks of kidneys were prepared for evaluating the histological changes due to diabetes. Histological study showed the deposit of eosinophilic materials in the intermediate substantial of medulla and thickening of renal arterial wall in the kidney of 70% of diabetic rats. The average weight of kidneys increased when compared to non diabetic animals. Furthermore, the amount of blood flow in arteries of all diabetic kidneys has been enhanced. The present study demonstrates some early renal histological changes in diabetes mellitus which were earlier compared to those reported previously. Diabetic nephropathy is a progressive disease and renal care design can help better prognosis achievement.
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نوع مطالعه: Original Article | موضوع مقاله: Histopathology
دریافت: 1392/8/8 | پذیرش: 1392/9/17 | انتشار: 1392/9/30
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