[صفحه اصلی ]   [Archive]  
:: صفحه اصلي :: درباره نشريه :: آخرين شماره :: تمام شماره‌ها :: جستجو :: ثبت نام :: ارسال مقاله :: تماس با ما ::
:: جلد 8 - ::
برگشت به فهرست نسخه ها
The Role of ERRFI1+808T/G Polymorphism in Diabetic Nephropathy
:   (676 مشاهده)
Nephropathy is a common diabetes complication. ERRFI1 gene which participates in various cellular pathways has been proposed as a candidate gene in diabetic nephropathy. This study aimed to investigate the role of +808T/G polymorphism (rs377349) in ERRFI1 gene in diabetic nephropathy. In this case-control study, patients including diabetes with nephropathy (DN=104), type 2 diabetes without nephropathy (DM=100), and healthy controls (HC=106) were included. DNA was extracted from blood, and genotyping of the +808T/G polymorphism was carried out using PCR-RFLP technique. The differences for genotype and allele frequencies for +808T/G polymorphism in ERRFI1 gene between DN vs. HC and DN+DM vs. HC were significant (P<0.05) while no significant difference between DN and DM was observed. The allele frequencies were significantly different in DN vs. HC and DN+DM vs. HC in males but not in females. G allele of +808T/G polymorphism in ERRFI1 gene has no significant role in development and progression of diabetic nephropathy in diabetes patients while it is a risk allele for developing diabetes in Iranian population.
متن کامل [PDF 89 kb]   (154 دریافت)    
نوع مطالعه: Original Article | موضوع مقاله: Genetics & Disease
دریافت: ۱۳۹۷/۱۲/۲۲ | پذیرش: ۱۳۹۸/۳/۱۶ | انتشار: ۱۳۹۸/۴/۱۴
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Asgarbeik S, Mohammad Amoli M, Enayati S, Bandarian F, Nasli-Esfahani E, Forouzanfar K, et al . The Role of ERRFI1+808T/G Polymorphism in Diabetic Nephropathy. Int J Mol Cell Med. 2019; 8 (S1)
URL: http://ijmcmed.org/article-1-1043-fa.html

The Role of ERRFI1+808T/G Polymorphism in Diabetic Nephropathy. مجله بین المللی سلولی و مولکولی. 1398; 8 (S1)

URL: http://ijmcmed.org/article-1-1043-fa.html



جلد 8 - برگشت به فهرست نسخه ها
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
Persian site map - English site map - Created in 0.08 seconds with 32 queries by YEKTAWEB 3991