International Journal of Molecular and Cellular Medicine
مجله بین المللی سلولی و مولکولی
Int J Mol Cell Med
Medical Sciences
http://ijmcmed.org
1
admin
2251-9637
2251-9645
10.22088/IJMCM.BUMS
en
jalali
1397
2
1
gregorian
2018
5
1
7
2
online
1
fulltext
en
The Growth Arrest-Specific Transcript 5 (GAS5) and Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1): Novel Markers Involved in Multiple Sclerosis
Genetics & Disease
Genetics & Disease
Original Article
Original Article
<div style="text-align: justify;">Recent studies have revealed that long non-coding RNAs (lncRNAs) are connected with pathogenesis of neurodegenerative diseases. Additionally, glucocorticoids have fundamental regulatory roles on the immune system, and act as potent therapeutic compounds for autoimmune and inflammatory diseases. The long noncoding RNA growth arrest-specific 5 (<em>GAS5</em>) which accumulates inside the cells in response to cellular starvation/growth arrest, acts as a potent repressor of the glucocorticoid receptor (GR) through its glucocorticoid response element (GRE). The aim of the present study was to investigate the role of lncRNA <em>GAS5</em> and its downstream target Nuclear Receptor Subfamily 3 Group C Member 1(<em>NR3C1</em>) in the pathogenesis of multiple sclerosis (MS), and to define the role of <em>GAS5</em> in the regulation of <em>NR3C1</em> expression. Quantitative polymerase chain reaction was performed for investigating the expression of <em>GAS5</em> and <em>NR3C1</em> in MS patients and healthy subjects. We found that <em>GAS5</em> levels were up-regulated in blood of MS patients compared with healthy subjects in correlation with <em>NR3C1</em> expression. Our findings suggest that<em> GAS5</em> may play important role in the molecular etiology and treatment of MS.</div>
Multiple sclerosis, GAS5, NR3C1
102
110
http://ijmcmed.org/browse.php?a_code=A-10-1391-1&slc_lang=en&sid=1
Jalal
Gharesouran
Gharesouranj@tbzmed.ac.ir
100319475328460011808
100319475328460011808
No
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad
Taheri
mohammad_823@yahoo.com
100319475328460011809
100319475328460011809
No
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Arezou
Sayad
ar.sayad@yahoo.com
100319475328460011810
100319475328460011810
No
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Soudeh
Ghafouri-Fard
ghafourifard@razi.tums.ac.ir
100319475328460011811
100319475328460011811
No
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mehrdokht
Mazdeh
Mazdeh.m@yahoo.com
100319475328460011812
100319475328460011812
No
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Mir Davood
Omrani
davood_omrani@yahoo.co.uk
100319475328460011813
100319475328460011813
Yes
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.