International Journal of Molecular and Cellular Medicine
مجله بین المللی سلولی و مولکولی
Int J Mol Cell Med
Medical Sciences
http://ijmcmed.org
1
admin
2251-9637
2251-9645
10.22088/IJMCM.BUMS
en
jalali
1392
3
1
gregorian
2013
6
1
2
2
online
1
fulltext
en
Homocysteine intracerebroventricular injection induces apoptosis in the Substantia Nigra cells and Parkinson like behavior in rat
Biomarkers (diagnosis & treatment)
Biomarkers (diagnosis & treatment)
Original Article
Original Article
Parkinson's disease is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain the cause of this cell death is unknown. Homocysteine (Hcy) is a non-protein amino acid. It is a homologue of the amino acid cysteine. The elevated levels of homocysteine in plasma have been associated with a number of disease states. Hcy (2 µmol / µl) was injected intracerebroventricular (i.c.v) in rats, five days later, the locomotor activity was measured with open field apparatus, Also apoptosis was investigated in substantia nigra cells by immunohistochemical analysis. Hcy could decrease locomotor activities significantly in rats as well as it could induce apoptosis in substantia nigra cells. These results suggest that Hcy is a neurotoxic metabolite and may induce cell death in some nuclei in the brain.
Homocysteine, parkinson disease, locomotor activity, substantia nigra, immunohistochemistry
80
85
http://ijmcmed.org/browse.php?a_code=A-10-79-2&slc_lang=en&sid=1
Amin
Ataie
ataieamin@yahoo.com
10031947532846003646
10031947532846003646
Yes
Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Science, Babol, Iran.
Ramin
Ataie
ramin_ataee@yahoo.com
10031947532846003647
10031947532846003647
No
Pharmaceutical Sciences Research Center, Department of Pharmacology and Toxicology Mazandaran, University of Medical Sciences, Sari, Iran.
Zahra
Mansouri
ataieamin@yahoo.com
10031947532846003648
10031947532846003648
No
Neuroscience research center. Shahid beheshti University of Medical Science, Tehran, Iran.
Seyed Mohsen
Aghajanpour
cmbrc.mubabol@gmail.com
10031947532846003649
10031947532846003649
No
Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Science, Babol, Iran.