en Genetics & Disease Genetics & Disease Original Article Original Article <p style="text-align: justify;">Diabetic dyslipidemia is one of the leading causes of coronary artery disease (CAD) death. Genetic and environmental factors play an important role in the development of type 2 diabetes mellitus (T2DM) and dyslipidemia. The present study was aimed to investigate the association of <em>ACE </em>(rs4646994),<em> FABP2 </em>(rs1799883), <em>MTHFR </em>(rs1801133) and<em> FTO </em>(rs9939609) genetic polymorphism in T2DM with dyslipidemia. Totally, 559 subjects including 221 T2DM cases with dyslipidemia, 158 T2DM without dyslipidemia and 180 controls were enrolled. <em>ACE</em> genetic polymorphism was evaluated by polymerase chain reaction (PCR), while <em>MTHFR</em>, <em>FABP2</em>, ​<em>FTO</em> genetic polymorphisms were evaluated by PCR and restriction fragment length polymorphism (RFLP). Significant association of <em>ACE</em> and <em>MTHFR</em> genetic polymorphisms were found in both group of cases [T2DM with dyslipidemia (P<0.001, and P=0.008, respectively) and T2DM without dyslipidemia (P=0.003, and P=0.010, respectively)] while <em>FABP2</em> and <em>FTO</em> genetic polymorphisms were significantly associated with T2DM without dyslipidemia (P=0.038, and P= 0.019, respectively). This study concludes that <em>ACE</em>, <em>FABP2</em>, <em>FTO</em> and <em>MTHFR</em> genes are associated with T2DM. Additionally, it also seems that <em>ACE</em> and <em>MTHFR</em> genes might be further associated with the development of dyslipidemia in T2DM cases.</p> <p></p> Genetic polymorphisms, type 2 diabetes mellitus (T2DM), dyslipidemia 121 130 http://ijmcmed.org/browse.php?a_code=A-10-1111-1&slc_lang=en&sid=1 Syed Tasleem Raza tasleem24@gmail.com 10031947532846009353 10031947532846009353 Yes Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Lucknow, India. Shania Abbas shania.abbas@gmail.com 10031947532846009354 10031947532846009354 No Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Lucknow, India. Zeba Siddiqi zsiddiqi9@gmail.com 10031947532846009355 10031947532846009355 No Department of Medicine Era’s Lucknow Medical College and Hospital, Lucknow, India. Farzana Mahdi farzana.mahdi@gmail.com 10031947532846009356 10031947532846009356 No Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Lucknow, India.