en Genetics & Disease Genetics & Disease Original Article Original Article Ameloblastic carcinoma (AC) is a rare malignant epithelial odontogenic tumor that histologically retains the features of ameloblastic differentiation and exhibits cytological features of malignancy in the primary or recurrent tumor. It may develop within a preexisting ameloblastoma or arise de novo or from an odontogenic cyst. Epidemiological evidence shows that human cancer is generally caused by genotoxic factors, genes involved in the susceptibility of cancer, including those involved in metabolism or detoxification of genotoxic environment and those controlling DNA replication. Nowadays, gene polymorphism has an important role in development of malignant tumor. We report a case series study of ameloblastic carcinoma and ameloblastoma to show the role of PKM2 and MAPK8IP2 polymorphisms in these tumors. The DNA was extracted separately from specimens in paraffin sections of the tumor. Polymorphism of these genes was determined by PCR-RFLP (Polymerase Chain Reaction-Restriction fragment length polymorphism) method. The allele distributions of all samples were in Hardy-Weinberg equilibrium. The genotype and allele distribution in these genes were not statistically different between patients and controls. Ameloblastic carcinoma, PKM2, MAPK8IP2, polymorphism 203 208 http://ijmcmed.org/browse.php?a_code=A-10-33-2&slc_lang=en&sid=1 Abbas Khodayari 10031947532846002339 10031947532846002339 No Department of Oral and Maxillofacial Surgery, Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Sayyed Mohammad Hossein Ghaderian sghaderian@yahoo.co.uk 10031947532846002340 10031947532846002340 Yes Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Jafarian 10031947532846002341 10031947532846002341 No Department of Oral and Maxillofacial Surgery, Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Alireza Jahangirnia alireza_omfs@yahoo.com 10031947532846002342 10031947532846002342 No Department of Oral and Maxillofacial Surgery,Shahid Beheshti University of Medical Sciences, Tehran, Iran. Alireza Nayebi 10031947532846002343 10031947532846002343 No Department of Oral and Maxillofacial Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Fahimeh Akhlaghi 10031947532846002344 10031947532846002344 No Department of Oral and Maxillofacial Surgery, Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Nasim Taghavi 10031947532846002345 10031947532846002345 No Department of oral and maxillofacial pathology, dental faculty,Shahid beheshty university of medical science,Tehran, Iran. Reza Akbarzadeh Najar rz_akbarzade@yahoo.com 10031947532846002346 10031947532846002346 No Department of Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Sanaz Tabarestani sanaztf@gmail.com 10031947532846002347 10031947532846002347 No Department of Genetics, Shahid Beheshti university of Medical Sciences, Tehran,Iran. Arash Khojasteh 10031947532846002348 10031947532846002348 No Department of Oral and Maxillofacial Surgery, Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Sarah Aghabozorg Afjeh s.afjeh@yahoo.com 10031947532846002349 10031947532846002349 No Department of Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.