en Genetics & Disease Genetics & Disease Review Review <p><span style="font-family:Tahoma;"><span style="font-size:11pt"><span style="line-height:107%"><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:107%">Dental implant integration is dependent on osteogenesis driven by the transcription factor SATB2, which regulates osteogenic genes. MicroRNAs (miRNAs) modulate SATB2 and influence bone formation. This review evaluates miRNA-SATB2 interactions, non-coding RNAs, and biomaterials in dental implant osseointegration.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:107%"><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:107%">A critical review of studies from 2015 to 2025 was conducted to elucidate miRNA-SATB2 interactions and their impact on osteogenesis.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:107%"><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:107%">Inhibitory miRNAs (e.g., miR-31, miR-140-5p) suppress SATB2 via the Wnt/&beta;-catenin or SIRT1/Smad3 pathways and reduce osteoblast differentiation. Promoter miRNAs (e.g., miR-17-5p, miR-27a-5p) enhance SATB2 through BMP/Smad signaling. Non-coding RNAs (e.g., lncRNA H19, hsa_circ_0007292) inhibit miRNAs affecting cancellous bone and promote osteogenesis. Biomaterials such as collagen/nanohydroxyapatite (Col/nHA) scaffolds and comorbidities (e.g., osteoporosis) influence outcomes. Inconsistent miRNA roles and limited in vivo data are key gaps.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:107%"><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:107%">miRNA- SATB2 interactions are critical for implant success. Patient-specific miRNA profiling and targeted therapies hold promise, pending clinical validation.</span></span></span></span></span></span></p> Non-Coding RNA, MicroRNA, SATB2, Osteogenesis, Dental Implants, Bone Fusion, Wnt Signaling, Biomaterials erials 1099 1109 http://ijmcmed.org/browse.php?a_code=A-10-8429-1&slc_lang=en&sid=1 Saad Alsaif saadalsaif48@gmail.com 100319475328460036824 0009-0006-5114-7821 Yes Restorative Department Prince Abdulrahman Advanced Dental Institute, Riyadh, Saudi Arabia Mousa Alrashidy 100319475328460036825 100319475328460036825 No Restorative Department Prince Abdulrahman Advanced Dental Institute, Riyadh, Saudi Arabia Saeed Al Dossary 100319475328460036826 100319475328460036826 No Restorative Department, Prince Abdulrahman Advanced Dental Institute, Riyadh, Saudi Arabia.