en Neurosciences Neurosciences Review Review <p style="text-align: justify;"><span style="font-family:Tahoma;"><span style="font-size:10.0pt"><span style="line-height:107%">Trace amine-associated receptor 1 (TAAR1) is a classical representative of G-protein coupled receptors (GPCRs). It is widely distributed in the mammalian brain, potentially plays an important role in modulating neurotransmitter functions and may regulate synaptic transmission and neuronal activity. Studies on TAAR1 signaling pathways were reviewed to identify the potential of TAAR1 as a novel target for neuroprotection and neurorepair. TAAR1 realizes effects through binding to the G-protein subunits Gas or Ga13. The target of Gas is PKA and the target of Ga13 is RhoA. Among the RhoA-mediated effects of TAAR1, effects on MAPK/ERK pathway kinases, AMPA and NMDA glutamate receptors and CREB factor have been investigated. RhoA-mediated effects include effects on the internalization of DAT and EAAT3, neuronal transporters of dopamine and glutamate. A G-protein independent pathway is mediated by &beta;-arrestin and is probably related to the formation of the TAAR1-D2R heterodimer. The modulatory effect of TAAR1 on neurotransmitter systems allows us to consider TAAR1 agonists as potential therapeutic agents for the treatment of neurodegenerative diseases and psychiatric disorders, as well as neuroprotectors in ischemic brain damage.</span></span></span></p> Trace amine-associated receptors, Signal transduction, Neuroprotection, Neurotransmitter agents, Cyclic AMP-dependent protein kinases 980 993 http://ijmcmed.org/browse.php?a_code=A-10-8202-1&slc_lang=en&sid=1 Mikhail Voevoda director@frcftm.ru 100319475328460036773 100319475328460036773 No Federal State Budgetary Scientific Institution and quot, Federal Research Center for Fundamental and Translational Medicine and quot, Novosibirsk, Russia. Dmitry Filimonov 100319475328460036774 100319475328460036774 Yes Federal State Budgetary Institution V.K. Gusak Institute of emergency and reconstructive surgery of the Ministry of health of the Russian Roman Knyazev raknyazev@frcftm.ru 100319475328460036775 100319475328460036775 No Federal State Budgetary Scientific Institution and quot, Federal Research Center for Fundamental and Translational Medicine and quot, Novosibirsk, Russia. Roman Ishchenko info@iursdn.ru 100319475328460036776 100319475328460036776 No Federal State Budgetary Institution V.K. Gusak Institute of emergency and reconstructive surgery of the Ministry of health of the Russian Alexander Eresko a_eresko77@mail.ru 100319475328460036777 100319475328460036777 No Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Russia. Nadezhda Trubnikova orenaji3@bk.ru 100319475328460036778 0009-0002-3407-5927 No Federal State Budgetary Institution V.K. Gusak Institute of emergency and reconstructive surgery of the Ministry of health of the Russian Margarita Belotserkovskaya margarita-amb@mail.ru 100319475328460036779 0009-0004-3019-144X No Federal State Budgetary Institution V.K. Gusak Institute of emergency and reconstructive surgery of the Ministry of health of the Russian Irina Kisilenko irinka.dn.15@gmail.com 100319475328460036780 0009-0006-6404-2930 No Federal State Budgetary Institution V.K. Gusak Institute of emergency and reconstructive surgery of the Ministry of health of the Russian Inna Nosova n_inna_n@mail.ru 100319475328460036781 0009-0005-4868-0345 No Federal State Budgetary Institution V.K. Gusak Institute of emergency and reconstructive surgery of the Ministry of health of the Russian Maksim Solopov mxsolopov@yandex.ru 100319475328460036782 100319475328460036782 No Federal State Budgetary Institution V.K. Gusak Institute of emergency and reconstructive surgery of the Ministry of health of the Russian