en Genetics & Disease Genetics & Disease Original Article Original Article <p><span style="font-size:12px;"><span style="font-family:Tahoma;"><span style="line-height:107%">Periodontitis is a chronic inflammatory condition affecting a large population all over the world. This condition is linked with abnormal expression of numerous genes. We measured levels of CYFIP1, KDR, RABGGTA, RABGGTB and FOXD2 in gingival tissue and circulation of people with periodontitis and healthy controls. KDR was more expressed in tissue samples of female patients compared with female controls (Ratio of mean expression (RME) =4.16, P=0.02). However, this gene was less expressed in the blood of female patients compared with female control subjects (RME=0.12, P=0.04). RABGGTB was less expressed in the blood of male patients compared with male controls (RME=0.20, P=0.02). Finally, FOXD2 was less expressed in total blood samples compared with total controls (RME=0.3, P<0.001) and in blood samples of female patients compared with female control subjects (RME=0.02, P<0.001). RABGGTA had the best area under curve (AUC) value in differentiation of patients&#39; tissues from normal tissues (AUC=0.60, sensitivity=0.37, specificity=0.92). In distinction of abnormal blood samples from controls, FOXD2 had the best performance (AUC=0.85, sensitivity=0.66, specificity=0.91). In brief, we demonstrated a sex-dependent dysregulation of KDR, RABGGTB and FOXD2 genes in circulation or tissue of patients with periodontitis.</span></span></span></p> CYFIP1, KDR, RABGGTA, RABGGTB, FOXD2, periodontitis 300 309 http://ijmcmed.org/browse.php?a_code=A-10-7163-1&slc_lang=en&sid=1 Soudeh Ghafouri-Fard soudehghafourifard@gmail.com 100319475328460033895 100319475328460033895 No Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Leila Gholami l.gholami@hotmail.com 100319475328460033896 100319475328460033896 No Department of Periodontics, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Elham Badrlou elhamb2@gmail.com 100319475328460033897 100319475328460033897 No Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Saba Sadeghpour saba225@gmail.com 100319475328460033898 100319475328460033898 No Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Naghme Nazer naghll@gmail.com 100319475328460033899 100319475328460033899 No Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran. Mahdi Shadnoush mShadnoush@gmail.com 100319475328460033900 100319475328460033900 No Department of Clinical Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Sheyda Khalilian sh.khalilian92@gmail.com 100319475328460033901 100319475328460033901 No Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Arezou Sayad ar.sayad@yahoo.com 100319475328460033902 100319475328460033902 Yes Dental Research Center, Research Institute for Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.