International Journal of Molecular and Cellular Medicine
مجله بین المللی سلولی و مولکولی
Int J Mol Cell Med
Medical Sciences
http://ijmcmed.org
1
admin
2251-9637
2251-9645
10.22088/IJMCM.BUMS
en
jalali
1393
6
1
gregorian
2014
9
1
3
4
online
1
fulltext
en
Histopathologic Responses of the Dental Pulp to Calcium-Enriched Mixture (CEM) and Mineral Trioxide Aggregate (MTA) in Diabetic and Non-Diabetic Rats
Histopathology
Histopathology
Original Article
Original Article
Diabetes mellitus is a chronic disease which affects the healing ability of the pulp and periodontium. The aim of the present study was to assess the histopathologic response of dental pulp to pulp capping using MTA or CEM cement in diabetic rats. Thirty two Wistar male rats aged between 8 and 10 weeks (weight: 200-250g) were divided into two groups of diabetic (n=16) and healthy (n=16) animals and then subdivided into MTA and CEM subgroups. In each group, 10 MTA treated, 10 CEM treated and 12 intact (without any intervention) teeth were analyzed. Intact teeth were considered as a baseline inflammation control. Then, class I cavity was made in the maxillary first molars teeth with pinpoint pulpal exposure. Either MTA or CEM cement was then placed over exposed pulp as pulp capping agent and the cavities were restored using resin- modified glass ionomer cement. Both teeth of rats in subgroups remained intact without any intervention. After four weeks, the rats were sacrificed and the teeth were subjected to histological evaluation in terms of inflammation intensity, dentin bridge formation and dentin bridge continuity. The CEM cement treated diabetic rats exhibited a significant higher inflammatory response when compared to healthy control group (P=0.004) whereas, MTA treated diabetic rats did not exhibit a significant higher inflammatory response in comparison to healthy controls. There was no significant difference between MTA and CEM cement in the induction of dentin bridge formation in diabetic and healthy controls. This preliminary study suggests that MTA is a superior dental material than CEM cement for pulp therapy in subjects with diabetes.
Diabetes, direct pulp capping, CEM cement, MTA
263
271
http://ijmcmed.org/browse.php?a_code=A-10-165-2&slc_lang=en&sid=1
Zahra Sadat
Madani
Madani_z@yahoo.com
10031947532846004128
10031947532846004128
No
Dental Materials Research Center Dental School, Babol University of Medical Sciences, Babol, Iran.
Azam
Haddadi
ddadi_azam@yahoo.com
10031947532846004129
10031947532846004129
Yes
Dental School, Mazandaran University of Medical Sciences, Sari, Iran.
Abbas
Mesgarani
A_mesgarani@yahoo.com
10031947532846004130
10031947532846004130
No
Dental School, Babol University of Medical Sciences Babol, Iran.
Maryam
Seyedmajidi
Ms_majidi79@yahoo.com
10031947532846004131
10031947532846004131
No
Dental Materials Research Center Dental School, Babol University of Medical Sciences, Babol, Iran.
Amrollah
Mostafazadeh
amrolah65@yahoo.com
10031947532846004132
10031947532846004132
No
Cellular& Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
Ali
Bijani
alibijani@yahoo.com
10031947532846004133
10031947532846004133
No
Non–Communicable Pediatric Diseases Research Center Babol University of Medical Sciences, Babol, Iran.
Manouchehr
Ashraphpour
mnr_ashraphpour@yahoo.com
10031947532846004134
10031947532846004134
No
Department of pharmacology and Neurosciences, Babol University of Medical Sciences, Babol, Iran.