International Journal of Molecular and Cellular Medicine
مجله بین المللی سلولی و مولکولی
Int J Mol Cell Med
Medical Sciences
http://ijmcmed.org
1
admin
2251-9637
2251-9645
10.22088/IJMCM.BUMS
en
jalali
1392
10
1
gregorian
2014
1
1
3
1
online
1
fulltext
en
Early Renal Histological Changes in Alloxan-Induced Diabetic Rats
Histopathology
Histopathology
Original Article
Original Article
Diabetes mellitus is a progressive disease. Most investigators have focused on glomerular changes in diabetic kidney and non-glomerular alterations have been less attended. The present study has been conducted to find early non-glomerular histological changes in diabetic renal tissue. Twenty male Wistar rats weighting 200-250 g were used for the diabetic group. Diabetes mellitus was induced by single injection of Alloxan. After 8 weeks, paraffin embedded blocks of kidneys were prepared for evaluating the histological changes due to diabetes. Histological study showed the deposit of eosinophilic materials in the intermediate substantial of medulla and thickening of renal arterial wall in the kidney of 70% of diabetic rats. The average weight of kidneys increased when compared to non diabetic animals. Furthermore, the amount of blood flow in arteries of all diabetic kidneys has been enhanced. The present study demonstrates some early renal histological changes in diabetes mellitus which were earlier compared to those reported previously. Diabetic nephropathy is a progressive disease and renal care design can help better prognosis achievement.
Key words: Diabetes mellitus, kidney, alloxan
11
15
http://ijmcmed.org/browse.php?a_code=A-10-63-4&slc_lang=en&sid=1
Mohsen
Pourghasem
mpourghasem@hotmail.com
10031947532846003525
10031947532846003525
No
Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran.
Ebrahim
Nasiri
ebrahimnasiri@yahoo.com
10031947532846003526
10031947532846003526
Yes
Department of Anatomical Sciences, Gilan University of Medical Sciences. Rasht, Iran.
Hamid
Shafi
dr_hamidshafi@yahoo.com
10031947532846003527
10031947532846003527
No
Department of Urology, Babol University of Medical Sciences, Babol, Iran.