International Journal of Molecular and Cellular Medicine
مجله بین المللی سلولی و مولکولی
Int J Mol Cell Med
Medical Sciences
http://ijmcmed.org
1
admin
2251-9637
2251-9645
10.22088/IJMCM.BUMS
en
jalali
1392
6
1
gregorian
2013
9
1
2
4
online
1
fulltext
en
Drug Resistance of Pseudomonas aeruginosa and Enterobacter cloacae Isolated from ICU, Babol, Northern Iran
Infectious disease (Molecular and Cellular aspects)
Infectious disease (Molecular and Cellular aspects)
Original Article
Original Article
Multidrug resistant (MDR) bacteria are spread through the world which causes nosocomial infections, especially in Intensive Care Unit (ICU). This study aimed to investigate resistance pattern of Pseudomonas aeruginosa and Enterobacter cloacae isolated from patients in ICU. During 2011-2012, 30 isolates for each P. aeruginosa and E. cloacae were collected from patients who acquired nosocomial infection after admition to the ICU at Hospitals affiliated to Babol University of Medical Sciences, Babol, northern Iran. Antimicrobial susceptibility test was performed for five category antibiotics by micro-dilution method. Data were analyzed by SPSS version 20 and p<0.05 was considered statistically significant. The highest resistance rate of P. aeruginosa was seen to amikacin (53.3%) followed by ceftazidime (43.3%). Also, 16.7% of E. cloacae was resistant to ceftazidime. Among P. aeruginosa isolates,18 (60%) were MDR while no E. cloacae isolates were MDR. The significant correlation was only demonstrated between MDR P. aeruginosa and the reason of hospitalization (P=0.004). In conclusion, there was alarming amount of P. aeruginosa MDR in patients in ICU which could lead to a hazardous outcome for the patients. Therefore, new prevention policies regarding to hospital infection should be established. Also, periodical assessment of bacterial resistance pattern particularly in ICUs should be performed.
Intensive care unit, nosocomial infections, P. aeruginos, E. cloacae
204
209
http://ijmcmed.org/browse.php?a_code=A-10-130-1&slc_lang=en&sid=1
Masomeh
Bayani
m_Bayani@yahoo.com
10031947532846003590
10031947532846003590
No
Infectious Disease and Tropical Research Center, Babol University of Medical Sciences, Babol, Iran.
Sepideh
Siadati
siadati_sepideh@yahoo.com
10031947532846003591
10031947532846003591
Yes
Department of Pathology, Babol University of Medical Sciences, Babol, Iran.
Ramzan
Rajabnia
RamzanR@yahoo.com
10031947532846003592
10031947532846003592
No
Infectious Disease and Tropical Research Center, Babol University of Medical Sciences, Babol, Iran.
Ali Asghar
Taher
10031947532846003593
10031947532846003593
No
Infectious Disease and Tropical Research Center, Babol University of Medical Sciences, Babol, Iran.