TY - JOUR JF - ijmcmed JO - Int J Mol Cell Med VL - 11 IS - 3 PY - 2022 Y1 - 2022/2/01 TI - Applying Vasopressin-Pre-Conditioned Human Adipose Mesenchymal Stem Cells Improves Heart Condition after Transplantation into Infarcted Myocardium TT - N2 - Transplantation of H-AdMSCs may improve heart function after MI. AVP is a neurohypophyseal hormone that reduces cardiovascular damage. This study investigated the role of AVP preconditioning in the survival of MSCs and their effect on myocardial repair in the MI rats. H-AMSCs were isolated and incubated for 3 days. The expression of oxytocin and vasopressin receptors was evaluated by Real-time-PCR. Forty male Wistar rats were divided into 4 groups: control, sham, ASC and AVP-ASC. Ischemia was established by ligation of LAD coronary artery. Electrocardiography, fibrosis, angiogenesis, and apoptosis in myocardium were determined after 7 days. Results showed that preconditioned MSCs significantly increased cardiac function when compared with group that received non-preconditioned MSCs. This was associated with significantly reduced fibrosis, increased vascular density, and decreased resident myocyte apoptosis. Results indicate that AVP preconditioned MSCs can be consider a novel approach to management of MI. SP - 207 EP - 222 AU - Nasiri Boroujeni, Shakiba AU - Chehelcheraghi, Farzaneh AU - Khaksarian, Mojtaba AU - Sedighi, Mehrnoosh AU - Ghorbanzadeh, Vajihe AU - Nazari, Afshin AD - Department of Physiology, Lorestan University of Medical Sciences, Khorramabad, Iran. KW - Myocardial infarction KW - Arginine vasopressin KW - fibrosis KW - apoptosis KW - angiogenesis KW - mesenchymal stem cells UR - http://ijmcmed.org/article-1-1997-en.html DO - 10.22088/IJMCM.BUMS.11.3.207 ER -