RT - Journal Article T1 - Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review JF - ijmcmed YR - 2021 JO - ijmcmed VO - 10 IS - 3 UR - http://ijmcmed.org/article-1-1707-en.html SP - 181 EP - 188 K1 - Diabetes K1 - complications K1 - mTOR K1 - mTOR complex 1 K1 - signaling AB - The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine-protein kinase that senses and combines various environmental signals to regulate the growth and homeostasis of human cells. This signaling pathway synchronizes many critical cellular processes and is involved in an increasing number of pathological conditions such as diabetes, cancer, obesity, and metabolic syndrome. Here, we review different complications of diabetes that are associated with mTOR complex 1 imbalance. We further discuss pharmacological approaches to treat diabetes complications linked to mTOR deregulation. LA eng UL http://ijmcmed.org/article-1-1707-en.html M3 10.22088/IJMCM.BUMS.10.3.181 ER -