RT - Journal Article T1 - The Biological Significance of Long noncoding RNAs Dysregulation and their Mechanism of Regulating Signaling Pathways in Cervical Cancer JF - ijmcmed YR - 2021 JO - ijmcmed VO - 10 IS - 2 UR - http://ijmcmed.org/article-1-1536-en.html SP - 75 EP - 100 K1 - Cervical cancer K1 - human papillomavirus K1 - long noncoding RNA K1 - signaling pathways K1 - gene regulation AB - Despite the remarkable decrease in cervical cancer incidence due to the availability of the HPV vaccine and implementation of screening programs for early detection in developed countries, this cancer remains a major health problem globally, especially in developing countries where most of the cases and mortality occur. Therefore, more understanding of molecular mechanisms of cervical cancer development might lead to the discovery of more effective diagnosis and treatment options. Research on long noncoding RNAs (lncRNAs) demonstrates the important roles of these molecules in many physiological processes and diseases, especially cancer. In the present review, we discussed the significance of lncRNAs altered expression in cervical cancer, highlighting their roles in regulating highly conserved signaling pathways, such as mitogen-activated protein kinase (MAPK), Wnt/β-catenin, Notch, and phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathways and their association with the progression of cervical cancer in order to bring more insight and understanding of this disease and their potential implications in cancer diagnosis and therapy. LA eng UL http://ijmcmed.org/article-1-1536-en.html M3 10.22088/IJMCM.BUMS.10.2.75 ER -