%0 Journal Article %A García-Muñoz, Alejandro %A Nieto-Velázquez, Nayeli Goreti %A Damian-Morales, Gabriela %A Liceaga-Escalera, Carlos %A Montoya-Perez, Luis Alberto %A Cruz-Vélez, Madeleine %A Gómez-Hernández, Pabel Antonio %A Trejo-Iriarte, Cynthia %A Pastelin-Palacios, Rodolfo %A Moreno-Eutimio, Mario %T PD-1, TIM-3, and LAG-3 Expression in T Cells in a Patient with Recurrent Ossifying Fibroma: A Case Report %J International Journal of Molecular and Cellular Medicine %V 9 %N 4 %U http://ijmcmed.org/article-1-1403-en.html %R 10.22088/IJMCM.BUMS.9.4.307 %D 2020 %K Immune checkpoint proteins, ossifying fibroma, programmed cell death 1 receptor, T-lymphocytes, %X Central ossifying fibroma is a benign, slow-growing tumor of mesenchymal origin with a predilection for the mandibular premolar and molar areas. The immunophenotype of T cells involved in the antitumor response against this benign tumor is unknown. In this case report, we described a case of a 48-year-old woman presenting with a very large recurrent ossifying fibroma in the mandible, which was successfully treated with hemimaxillectomy. In addition, we evaluated the expression of programmed cell death 1 receptor (PD-1), lymphocyte activation gene-3 (LAG-3), T cell immunoglobulin and mucin-domain containing-3 (TIM-3), cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), CD69 (activation inducer molecule) and CD25 (α chain of the high-affinity IL-2 receptor) in T cell populations from the tumor and peripheral blood of this uncommon lesion. The patient presented recurrent ossifying fibroma, and the tumor-infiltrating and peripheral blood T cells showed expression of PD-1, LAG-3, and TIM-3, suggesting an exhausted T cell response. %> http://ijmcmed.org/article-1-1403-en.pdf %P 307-311 %& 307 %! Immunophenotype of a case of ossifying fibroma %9 Case Report %L A-10-2913-1 %+ Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (FES-Iztacala UNAM), Estado de México, México. %G eng %@ 2251-9637 %[ 2020