%0 Journal Article %A Taghipour Fard Ardekani, Mehdi %A Malekzadeh, Mahyar %A Vahid Hosseini, Mohammad %A Bordbar, Elahe %A Mojtahei, Zahra %A Doroudchi, Mehrnoosh %A Ghaderi, Abbas %T Evaluation of pre-treatment serum levels of IL-7 and GM-CSF in colorectal cancer patients %J International Journal of Molecular and Cellular Medicine %V 3 %N 1 %U http://ijmcmed.org/article-1-112-en.html %R %D 2014 %K Colorectal cancer, Serum, GM-CSF, IL-7, %X Background: Survival of Colorectal cancer (CRC) patients is considerably stage-dependent therefore, early diagnosis is a pivotal factor in decreasing mortality and morbidity associated with this cancer. GM-CSF and IL-7 are reported to increase in different cancers and we aim to investigate the pre-treatment serum levels of GM-CSF and IL-7 in Iranian patients with colorectal cancer. Methods: 127 patients (68 males and 59 females) before receiving chemotherapy or radiotherapy entered to this study. A control group of 50 healthy age/sex matched individuals (27 males and 23 females) were included in the study. Serum levels of GM-CSF and IL-7 were measured using commercial enzyme linked immunosorbent assays. Results: A significantly higher level of GM-CSF was found in the sera of patients with colorectal cancer compared with healthy age/sex matched controls (p=0.013). However, there was no significant difference between the levels of IL-7 in sera of patients and controls. We observed a significant elevation in the level of GM-CSF in poorly differentiated tumors (p=0.024). Also a significant correlation between lymphatic invasion and the level of GM-CSF in sera of CRC patients was detected (p=0.01). We found an increase in the level of IL-7 in the three patients in the moderate stages of the tumor concomitant with a decrease in the level of GM-CSF. Conclusion: Increase in the level of GM-CSF is accompanied by CRC progression in Iranian patients, while there may be a potential therapeutic effect of IL-7 in this disease. %> http://ijmcmed.org/article-1-112-en.pdf %P 26-34 %& 26 %! GM-CSF but not IL-7 increases during CRC progression %9 Original Article %L A-10-150-1 %+ Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. %G eng %@ 2251-9637 %[ 2014