:: Volume 4, Issue 3 (Int J Mol Cell Med 2015) ::
Int J Mol Cell Med 2015, 4(3): 188-195 Back to browse issues page
Impact of Propionic Acid on Liver Damage in Rats
Sooad Al- daihan1, Ramesa Shafi Bhat 2
1- Cellular Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia.
2- Cellular Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia. , rbhat@ksu.edu.sa
Abstract:   (19771 Views)

Propionic acid (PA) is a short chain fatty acid, a common food preservative and metabolic end product of enteric bacteria in the gut. The present study was undertaken to investigate the effect of PA on liver injury in male rats. Male western albino rats were divided into two groups. The first group served as normal control, the second was treated with PA. The activities of serum hepatospecific markers such as aspartate transaminase, alanine transaminase, and alkaline phosphatase were estimated. Antioxidant status in liver tissues was estimated by determining the level of lipid peroxidation and activities of enzymatic and non-enzymatic antioxidants. Sodium and potassium levels were also measured in liver tissue. PA treatment caused significant changes in all hepatospecific markers. Biochemical analysis of liver homogenates from PA-treated rats showed an increase in oxidative stress markers like lipid peroxidation and lactate dehydrogenase, coupled with a decrease in glutathione, vitamin C and glutathione S- transferase. However, PA exposure caused no change in sodium and potassium levels in liver tissue. Our study demonstrated that PA persuade hepatic damage in rats.

Keywords: Propionic acid, liver, oxidative stress
Full-Text [PDF 132 kb]   (3056 Downloads)    
Type of Study: Original Article | Subject: Clinical Biochemistry
Received: 2015/02/3 | Accepted: 2015/03/14 | Published: 2015/06/29


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Volume 4, Issue 3 (Int J Mol Cell Med 2015) Back to browse issues page