دوره 4، شماره 2 - ( 12-1393 )                   | برگشت به فهرست نسخه ها

XML English Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Jha S K, Jha N K, Kar R, Ambasta R K, Kumar P. p38 MAPK and PI3K/AKT signalling cascades in Parkinson’s disease. Int J Mol Cell Med 2015; 4 (2) :67-86
URL: http://ijmcmed.org/article-1-267-fa.html
p38 MAPK and PI3K/AKT signalling cascades in Parkinson’s disease. مجله بین المللی سلولی و مولکولی. 1393; 4 (2) :67-86

URL: http://ijmcmed.org/article-1-267-fa.html

p38 MAPK and PI3K/AKT signalling cascades in Parkinson’s disease
:   (10963 مشاهده)
Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second largest incidence rate among all other neurodegenerative disorders barring Alzheimer's disease (AD). Currently there is no cure and researchers continue to probe the therapeutic prospect in cell cultures and animal models of PD. Out of several factors contributing to PD prognosis, the role of p38 MAPKs (mitogen-activated protein (MAP) kinase) and PI3K/AKT signalling module in PD brains is crucial because impaired balance between the pro-apoptotic and anti-apoptotic pathways trigger unwanted phenotypes such as microglia activation, neuroinflammation, oxidative stress, and apoptosis. These factors continue challenging the brain homeostasis in initial stages thereby essentially assisting the dopaminergic (DA) neurons towards progressive degeneration in PD. Neurotherapeutics against PD shall then be targeted against the misregulated accomplices of the p38 and PI3K/AKT cascades. In this review, we have outlined many such established mechanism involving the p38 MAPK and PI3K/AKT pathways which can offer therapeutic windows for rectification of aberrant DA neuronal dynamics in PD brains.
متن کامل [PDF 286 kb]   (5890 دریافت)    
نوع مطالعه: Review | موضوع مقاله: Medical Pharmacology
دریافت: 1393/9/19 | پذیرش: 1393/10/13 | انتشار: 1393/12/23
ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA
بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به International Journal of Molecular and Cellular Medicine IJMCM می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2025 CC BY-NC 4.0 | International Journal of Molecular and Cellular Medicine IJMCM

Designed & Developed by : Yektaweb