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Lack of Association Between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis
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Mohammad Naderi1   , Mohammad Hashemi 2, Parisa Khorgami1 , Maliheh Koshki1 , Mahboubeh Ebrahimi3 , Shadi Amininia3 , Batool Sharifi-Mood1 , Mosen Taheri4 |
1- Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
2- Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. , mhd.hashemi@gmail.com
3- Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
4- Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. |
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Abstract: (10772 Views) |
| Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was performed on 202 PTB patients and 204 healthy individuals. Genotyping was performed using tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). The results indicated that neither miRNA-499 rs3746444 nor miRNA-146a rs2910164 are associated with the risk of PTB in a sample of Iranian population. Larger studies with different ethnicities are required to validate our findings. |
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| Keywords: Tuberculosis, microRNA, miRNA-146a, miRNA-499, polymorphism |
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Full-Text [PDF 60 kb]
(3210 Downloads)
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Type of Study: Original Article |
Subject:
Infectious disease (Molecular and Cellular aspects)
Received: 2014/10/10 | Accepted: 2014/11/26 | Published: 2015/01/12
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