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The Biological Significance of Long noncoding RNAs Dysregulation and their Mechanism of Regulating Signaling Pathways in Cervical Cancer
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Maryame Lamsisi1  , Lahcen Wakrim2, Amal Bouziyane1, Mustapha Benhessou1, Mounia Oudghiri3, Abdelilah Laraqui4, Mohamed Elkarroumi5, Mohammed Ennachit5, Mohammed El Mzibri6, Moulay Mustapha Ennaji 7 |
1- Team of Virology, Oncology and Medical Biotechnologies, Laboratory of Virology, Microbiology, Quality, and Biotechnologies/ ETB. Faculty of Science and Techniques Mohammedia, Hassan II University of Casablanca, Morocco.
2- Laboratory of Virology, Pasteur Institute of Morocco, Casablanca, Morocco.
3- Immunology and Biodiversity laboratory, Faculty of Sciences Ain chock, Hassan II University of Casablanca, Morocco.
4- Research and Biosafety Laboratory, Mohammed V Military Hospital, University Mohammed V of Rabat, Morocco.
5- School of Medicine and Pharmacy, University Hassan II of Casablanca, Morocco.
6- Biology and Medical Research Unit, CNESTEN, Rabat, Morocco.
7- Team of Virology, Oncology and Medical Biotechnologies, Laboratory of Virology, Microbiology, Quality, and Biotechnologies/ ETB. Faculty of Science and Techniques Mohammedia, Hassan II University of Casablanca, Morocco. , m.ennaji@yahoo.fr |
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Abstract: (1975 Views) |
| Despite the remarkable decrease in cervical cancer incidence due to the availability of the HPV vaccine and implementation of screening programs for early detection in developed countries, this cancer remains a major health problem globally, especially in developing countries where most of the cases and mortality occur. Therefore, more understanding of molecular mechanisms of cervical cancer development might lead to the discovery of more effective diagnosis and treatment options. Research on long noncoding RNAs (lncRNAs) demonstrates the important roles of these molecules in many physiological processes and diseases, especially cancer. In the present review, we discussed the significance of lncRNAs altered expression in cervical cancer, highlighting their roles in regulating highly conserved signaling pathways, such as mitogen-activated protein kinase (MAPK), Wnt/β-catenin, Notch, and phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathways and their association with the progression of cervical cancer in order to bring more insight and understanding of this disease and their potential implications in cancer diagnosis and therapy. |
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| Keywords: Cervical cancer, human papillomavirus, long noncoding RNA, signaling pathways, gene regulation |
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Full-Text [PDF 970 kb]
(673 Downloads)
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Type of Study: Review |
Subject:
Cancer
Received: 2020/12/24 | Accepted: 2021/08/1 | Published: 2021/05/30
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