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Aberrant Expression of Immune-related MicroRNAs in Pediatric Patients with Asthma
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MicroRNAs (miRNAs) have been implicated as regulatory molecules that could play a considerable role in the pathogenesis of different diseases including asthma. This work aims at exploring the role of miR-146a and miR-106b in the pathogenesis of asthma and their association with asthma severity, IgE, and inflammatory cytokines in asthmatic children. Thirty asthmatic children and twenty age-matched healthy children aged 4-17 years old were enrolled. Expression of plasma miR-146a and miR-106b was measured using quantitative real-time PCR. Plasma levels of interleukin-5 (IL-5) and interleukin-13 (IL-13) were assessed using ELISA. Lung functions were measured by Spirometry. MiR-146a and miR-106b were significantly over-expressed in asthmatic children compared to healthy children. A significant positive correlation between total IgE and both miR-146a and miR-106b was found while no significant correlation could be detected between these miRNAs and asthma severity in asthmatic children. Plasma levels of IL-5 and IL-13 were non-significantly higher in asthmatic children compared to healthy children, and there was no significant correlation between them and both miR-146a and miR-106b expressions in the asthmatic children.  The aberrant expression of immune-related miRNAs (miR-146a and miR-106b) and inflammatory cytokines (IL-5 and IL-13) among asthmatic children suggest their probable role in asthma pathogenesis.
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نوع مطالعه: Original Article | موضوع مقاله: Molecular & Cellular Immunology
دریافت: 1399/6/17 | پذیرش: 1399/10/15 | انتشار: 1399/9/10
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Elnady H G, Sherif L S, Kholoussi N M, Azzam M A, Foda A R, Helwa I, et al . Aberrant Expression of Immune-related MicroRNAs in Pediatric Patients with Asthma. Int J Mol Cell Med. 2020; 9 (4) :246-254
URL: http://ijmcmed.org/article-1-1437-fa.html

Aberrant Expression of Immune-related MicroRNAs in Pediatric Patients with Asthma. مجله بین المللی سلولی و مولکولی. 1399; 9 (4) :254-246

URL: http://ijmcmed.org/article-1-1437-fa.html



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دوره 9، شماره 4 - ( 8-1399 ) برگشت به فهرست نسخه ها
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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