:: Volume 8, Issue 2 (Int J Mol Cell Med 2019) ::
Int J Mol Cell Med 2019, 8(2): 162-168 Back to browse issues page
Association between CYP19A <G rs700518 Polymorphism with Acne Vulgaris and its Severity: Influence on Sex Hormones Level
Ali Ebrahimi1, Zohreh Rahimi 2, Zomorod Ghadami1, Ebrahim Shakiba3, Ziba Rahimi1, Mona Akbari1, Mehrangiz Shafie3, Fariborz Bahrehmand1, Asad Vaisi-Raygani4, Rozita Naseri5
1- Department of Dermatology, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2- Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. , zrahimi@kums.ac.ir
3- Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
4- Fertility and Infertility Research Center, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran.
5- Department of Internal Medicine, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Abstract:   (2925 Views)
Acne vulgaris (AV) is a common skin disease that causes physical and psychological problems for affected individual. In addition to systemic changes in hormone levels, overproduction of local steroids, especially androgens are associated with AV. Cytochrome (CYP) 19 is involved in the synthesis of estrogens. The aim of the present study was to investigate the influence of CYP19A.
Keywords: Acne vulgaris, CYP19, estradiol, SHBG, androgens
Full-Text [PDF 346 kb]   (878 Downloads)    
Type of Study: Original Article | Subject: Genetics & Disease
Received: 2019/01/18 | Accepted: 2019/07/19 | Published: 2020/02/5

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Volume 8, Issue 2 (Int J Mol Cell Med 2019) Back to browse issues page