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:: Volume 10, Issue 1 (Int J Mol Cell Med 2021) ::
Int J Mol Cell Med 2021, 10(1): 34-44 Back to browse issues page
Differential Expression and Prognostic Significance of STARD3 Gene in Breast Carcinoma
Abdul Fattah Salah Fararjeh 1, Ali Al Khader2 , Ezidin Kaddumi3 , Maher Obeidat4 , O'la AL-Fawares4
1- Department of Medical Laboratory Analysis, Faculty of Science, Al-Balqa Applied University, Al-salt, Jordan. , Fararjehas@bau.edu.jo
2- Department of Pathology and forensic medicine, Al-Balqa Applied University.
3- Department of Basic Medical Sciences, Faculty of Medicine, Al-Balqa Applied University, Al-salt, Jordan.
4- Department of Medical Laboratory Analysis, Faculty of Science, Al-Balqa Applied University, Al-salt, Jordan.
Abstract:   (308 Views)
StAR related lipid transfer domain containing 3 (STARD3) gene has been reported to be co-amplified with human epidermal growth factor receptor 2 (HER2) in breast carcinoma. STARD3 is necessary for cholesterol transfer and metabolism in tumor cells. The possible role played by STARD3 as a diagnostic and prognostic biomarker was investigated in breast cancer (BC). Data mining was performed using several bioinformatics websites to investigate the correlation of STARD3 with BC and its molecular subtypes, and conventional PCR was used to detect the STARD3 mRNA levels in a panel of BC cell lines. STARD3 was overexpressed in BC more than the other types of cancer. The results also showed that STARD3 expression was significantly associated with HER2+ BC tumors and BC cell lines, and low STARD3 mRNA and protein expression levels were observed in estrogen receptor-positive (ER+) and triple-negative BC (TNBC) patients. Moreover, high STARD3 expression levels predicted worse overall survival (OS), relapse-free survival (RFS) and disease metastasis-free survival (DMFS) in BC, and HER2+ BC. Notably, low expression of STARD3 was associated with poor OS in ER+ BC. Our findings suggest that STARD3 may have strong diagnostic and prognostic value for HER2+ breast carcinoma.
Keywords: Breast neoplasm, STARD3, HER2, prognosis, computational biology
Full-Text [PDF 699 kb]   (86 Downloads)    
Type of Study: Original Article | Subject: Cancer
Received: 2020/12/9 | Accepted: 2021/04/21 | Published: 2021/01/21
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Fararjeh A F S, Al Khader A, Kaddumi E, Obeidat M, AL-Fawares O. Differential Expression and Prognostic Significance of STARD3 Gene in Breast Carcinoma. Int J Mol Cell Med. 2021; 10 (1) :34-44
URL: http://ijmcmed.org/article-1-1525-en.html


Volume 10, Issue 1 (Int J Mol Cell Med 2021) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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