International Journal of Molecular and Cellular Medicine
مجله بین المللی سلولی و مولکولی
Int J Mol Cell Med
Medical Sciences
http://ijmcmed.org
1
admin
2251-9637
2251-9645
10.22088/IJMCM.BUMS
en
jalali
1398
4
1
gregorian
2019
7
1
8
2
online
1
fulltext
en
Protective Effect of Naringin on Bisphenol A-Induced Cognitive Dysfunction and Oxidative Damage in Rats
Neurosciences
Neurosciences
Original Article
Original Article
<div style="text-align: justify;">Bisphenol A (BPA) is one of the highest volume chemicals produced worldwide, which is used in many plastic industries. The present study aimed to evaluate the effect of BPA on cognitive functions and oxidative stress, and determine whether the naringin (NG) co-administration can modify the effect of this compound on cognitive functions and inhibit any possible oxidative stress in the brain tissue of rats. Adult male Wistar rats were divided into six groups. Group I: control, Group II: BPA-treated rats (50 mg/kg/day), Group III, IV, V: BPA+NG (40, 80, 160 mg/kg/day), Group VI: NG (160 mg/kg/day) alone. Cognitive functions were evaluated using step-down latency (SDL) on a passive avoidance apparatus, and transfer latency (TL) in elevated plus-maze. A significant decrease in SDL, prolongation of TL, noticeable oxidative impairment and increase in acetylcholinesterase activity were observed in the BPA-treated in comparison with the control group. Also, the co-administration of NG (160 mg/kg) antagonized the effect of BPA on SDL and TL, attenuated oxidative damage by lowering malondialdehyde and nitrite concentrations and restored superoxide dismutase, catalase, and glutathione S-transferase activities. On the other hand, acetylcholinesterase activity was reduced in the groups co-administred with NG (80 or 160 mg/kg) and BPA in comparison with the BPA alone-treated group. The present study highlighted the therapeutic potential of NG against BPA-induced cognitive impairment and oxidative damage.</div>
Bisphenol A, naringin, cognitive dysfunction, oxidative stress
141
153
http://ijmcmed.org/browse.php?a_code=A-10-1700-1&slc_lang=en&sid=1
Masoud
Mahdavinia
mahdavimasoud@yahoo.com
100319475328460015594
100319475328460015594
No
Department of Pharmacology and Toxicology, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran.
Akram
Ahangarpour
akramahangarpour@gmail.com
100319475328460015595
100319475328460015595
No
Health Research Institute, Diabetes Research Center, Department of Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Leila
Zeidooni
leilazeidooni@gmail.com
100319475328460015596
100319475328460015596
No
Department of Toxicology, School of Pharmacy, Student Research Committee of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Azin
Samimi
azin.samimi831@gmail.com
100319475328460015597
100319475328460015597
No
Department of Toxicology, School of Pharmacy, Student Research Committee of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Saeid
Alizadeh
Alizadeh.S@ajums.ac.ir
100319475328460015598
100319475328460015598
No
Department of Toxicology, School of Pharmacy, Student Research Committee of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Mohammad Amin
Dehghani
mohammaddeh83@yahoo.com
100319475328460015599
100319475328460015599
No
Department of Toxicology, School of Pharmacy, Student Research Committee of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Soheila
Alboghobeish
alboghobeish.s@ajums.ac.iir
100319475328460015600
100319475328460015600
Yes
Department of Pharmacology, School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran.