en Histopathology Histopathology Original Article Original Article Gastric adenocarcinoma is the second leading cause of death due to cancer in the world and in advanced stages the prognosis is poor with current therapies. Over-expression of HER-2/neu has been seen in several cancers such as gastric cancer and its expression is associated with poor prognosis. The aim of this study is to evaluate the over-expression of HER-2/neu in gastric biopsy samples of patients with gastric carcinoma diagnosis and to evaluate its probable relationship with clinical and pathological findings. The over-expression of HER-2/neu was examined retrospectively by immunohistochemistry method in 60 paraffin embedded samples collected in Babol, Iran, between 2010 and 2011. The over-expression of HER-2/neu has been observed in 6 patients (10%) and this over-expression was greater in the intestinal type of gastric adenocarcinoma than the diffuse type (12% vs. 6%) however, no statistically significant correlation between HER-2/neu expression and subtype, degree of differentiation, tumor type and age was observed. This over-expression was greater in differentiated types than undifferentiated types (18% vs. 5%). HER-2/neu, gastric cancer, immunohistochemistry 199 203 http://ijmcmed.org/browse.php?a_code=A-10-57-2&slc_lang=en&sid=1 Kourosh Movagharnejad K_movaghar@yahoo.com 10031947532846003585 10031947532846003585 No Department of pathology, Rohani hospital, Babol University of Medical Sciences, Babol, Iran. Majid Sharbatdaran sharbatdaran@yahoo.com 10031947532846003586 10031947532846003586 Yes Department of pathology, Rohani hospital, Babol University of Medical Sciences, Babol, Iran. Shahryar Shefaee shefaee@yahoo.com 10031947532846003587 10031947532846003587 No Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. Mehrdad Kashifard kashifard@yahoo.com 10031947532846003588 10031947532846003588 No Department of Internal medicine , Rohani hospital, Babol University of Medical Sciences, Babol, Iran. Sadegh Sedaghat sedaghat@yahoo.com 10031947532846003589 10031947532846003589 No Department of Hematology and Oncology, Rohani hospital, Babol University of Medical Sciences, Babol, Iran.