en Genetics & Disease Genetics & Disease Original Article Original Article <p style="text-align: justify;">Long intergenic non-coding RNA (lincRNA) has been introduced as key regulators of diverse biological processes, including transcription, chromatin organization, cell growth and tumorigenesis. With regard to the potential role of lincRNAs in cancer development, one may postulate that differential expression of lincRNAs could be employed as a tool in cancer diagnosis, prognosis, and targeted therapy. In this study, we aimed to explore the putative correlation between the expression levels of two lincRNAs: <em>LINC00152</em> and <em>LINC01082</em> in the bladder cancer (BC), in comparison with its adjacent non-cancerous tissue. Fifty Iranian subjects diagnosed with BC, representing in different stages and grades participated in this study.. The mRNA expression levels of the above mentioned lincRNAs were analyzed comparatively in cancerous and their adjacent non-cancerous counterpart tissues, of each subject by Real-Time PCR. The expression levels of <em>LINC00152</em>, and <em>LINC01082</em> were significantly lower in tumor tissues in comparison with their adjacent normal tissues (P< 0.001). More notably, in the case of <em>LINC01082</em> the reduced expression was differentiated by the muscle invasiveness pattern of the tumor (P= 0.05). Our study bestow a new finding about the tumor suppressor potentiality of these lincRNAs in BC development that in turn may suggest them as candidate biomarkers. Replicating this study in higher number of BC subjects, coupled with functional analysis, is necessary to investigate inter-connections between these RNAs and cancer development, leading to better understanding of cancer biology.</p> Bladder cancer, long intergenic non-coding RNA (lincRNA), LINC00152, LINC01082 212 221 http://ijmcmed.org/browse.php?a_code=A-10-1228-1&slc_lang=en&sid=1 Zahra Ousati Ashtiani ousati@tums.ac.ir 100319475328460010770 100319475328460010770 No Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Gholamreza Pourmand pourmand@tums.ac.ir 100319475328460010771 100319475328460010771 No Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Seyed Alireza Salami asalami@tums.ac.ir 100319475328460010772 100319475328460010772 No Department of Biotechnology, University of Tehran, Tehran, Iran. Mohsen Ayati mayati@tums.ac.ir 100319475328460010773 100319475328460010773 No Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Javad Tavakkoly Bazzaz tavakkolybazzazj@tums.ac.ir 100319475328460010774 100319475328460010774 Yes Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.