en Clinical Biochemistry Clinical Biochemistry Original Article Original Article In Persian traditional medicine is believed that camphor (a crystalline ketone obtained from cinnamomum camphora) is a suppressor of sexual behaviors. This study examined the central effects of camphor on sexual hormones (LH, FSH and testosterone) and GnRH plasma levels in male rat. Male Wistar rats weighing 250-260gr were selected and divided into control (no treatment), sham (ICV injection of EtOH 10%) and treatment (ICV injection of camphor in three doses 4, 20, 40 µg/ 10µl in alcohol) groups. The serum samples were used for assaying of GnRH, LH, FSH and testosterone. There were no significant differences in the levels of hormones between the groups of study. Despite the central administration of camphor in hypothalamus - pituitary - gonad (HPG) axis, no significant differences were seen in sex hormone`s levels compared to the control. With this finding, it can be concluded that camphor may not effectively handle the axis via central pathway. These data recommend further studies of camphor on the HPG axis. Camphor, GnRH, LH, FSH,Testosterone, Hypothalamus - Pituitary - Gonad (H-P-G) Axis 191 196 http://ijmcmed.org/browse.php?a_code=A-10-97-1&slc_lang=en&sid=1 sima shahabi sima.shahabi@ymail.com 10031947532846002324 10031947532846002324 Yes Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. Seyed Gholam Ali Jorsaraei alijorsara@yahoo.com 10031947532846002325 10031947532846002325 No Fatemeh Zahra Fertility and Infertility Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran. Ali Akbar Moghadamnia moghadamnia@yahoo.com 10031947532846002326 10031947532846002326 No Department of Physiology and Pharmacology, Babol University of Medical Sciences, Babol, Iran. Ebrahim Zabihi E_zabihi@yahoo.com 10031947532846002327 10031947532846002327 No Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. Seyed Mohsen Aghajanpour Mir mohsenaghajanpour@gmail.com 10031947532846002328 10031947532846002328 No Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. Seyedeh Narges Mousavi Kani 10031947532846002329 10031947532846002329 No Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. Roghiyeh Pourbagher Pourbagher_17@yahoo.com 10031947532846002330 10031947532846002330 No Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. Seyed Ahmad Hosseini 10031947532846002331 10031947532846002331 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Mohsen Esmaili drmesmaili 10031947532846002332 10031947532846002332 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Ali Asghar Yoonesi yoonesi325@yahoo.com ‎ 10031947532846002333 10031947532846002333 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Amin Zarghami 10031947532846002334 10031947532846002334 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Farid Alinezhad 10031947532846002335 10031947532846002335 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran.