International Journal of Molecular and Cellular Medicine
مجله بین المللی سلولی و مولکولی
Int J Mol Cell Med
Medical Sciences
http://ijmcmed.org
1
admin
2251-9637
2251-9645
10.22088/IJMCM.BUMS
en
jalali
1396
5
1
gregorian
2017
8
1
6
3
online
1
fulltext
en
Local Allergic Rhinitis in Pediatric Patients: is IgE Dosage in Nasal Lavage Fluid a Usefull Diagnostic Method in Children?
Biomarkers (diagnosis & treatment)
Biomarkers (diagnosis & treatment)
Original Article
Original Article
<p style="text-align: justify;">Local Allergic Rhinitis (LAR) is an emerging disease. However, its incidence in the pediatric population has not yet been studied. The gold-standard for the diagnosis is the nasal provocation test that is not everywhere available and difficult to apply in children. The aim of our study is to evaluate the nasal lavage fluid IgE as a biomarker of LAR in children. 54 pediatric patients [IQR 4.0-12.0 years] were divided into 3 groups: study group (26 children with rhinitis symptoms and without evidence of systemic atopy); allergic rhinitis (AR) group (15 children) and 13 healthy controls (HC). Every child was subjected to nasal lavage using 2 ml/nostril of the physiologic saline solution, that was therefore analyzed by ImmunoCAP to obtain the IgE concentration. Rhinofibroscopy and nasal cytology were performed. Our data show the presence of higher value of nasal lavage fluid IgE (average of 6.005 UI/ml; range: 4.47-7.74 UI/ml) in 16 out of 26 patients of the study group who therefore may be classified as affected by LAR. We observed a statistically significant difference (P< 0.0001) between NAR/HC group and LAR group, identifying a cut-off of 3.85 UI/ml. Finally, we found a better response to previous AR therapy in the LAR group than in the NAR group. Our data show the high incidence of LAR in pediatric patients previously classified as NAR. The measurement of IgE in nasal lavage fluid may be considered an easy and rapid method for the diagnosis of LAR in children. Besides, our data adds confirmatory evidences about the good response of LAR children to the classic AR therapy.</p>
Local allergic rhinitis, nasal lavage fluid, IgE, children, non-allergic rhinitis with eosinophilia syndrome (NARES)
174
182
http://ijmcmed.org/browse.php?a_code=A-10-762-2&slc_lang=en&sid=1
Laura
Colavita
lauracol85@gmail.com
100319475328460010570
100319475328460010570
Yes
Department of Pediatrics, Hospital “Umberto I°” of Siracusa, Siracusa, Italy.
Natalia
Catalano
nataliacatalano@alice.it
100319475328460010571
100319475328460010571
No
Department of Otolaryngology, University Hospital of Messina, Messina, Italy.
Giovanna
Sposito
gibi51@gmail.com
100319475328460010572
100319475328460010572
No
Department of Laboratory Diagnostics, Unit of Clinical Pathology, University Hospital of Messina, Messina, Italy.
Saverio
Loddo
sloddo@unime.it
100319475328460010573
100319475328460010573
No
Department of Laboratory Diagnostics, Unit of Clinical Pathology, University Hospital of Messina, Messina, Italy.
Bruno
Galletti
bgalletti@unime.it
100319475328460010574
100319475328460010574
No
Department of Otolaryngology, University Hospital of Messina, Messina, Italy.
Carmelo
Salpietro
cdsalpietro@unime.it
100319475328460010575
100319475328460010575
No
Department of Adult and Childhood Human Pathology, Unit of Genetics and Pediatric Immunology, University Hospital of Messina, Messina, Italy.
Francesco
Galletti
francesco.galletti@unime.it
100319475328460010576
100319475328460010576
No
Department of Otolaryngology, University Hospital of Messina, Messina, Italy.
Caterina
Cuppari
katia.cuppari@libero.it
100319475328460010577
100319475328460010577
No
Department of Adult and Childhood Human Pathology, Unit of Genetics and Pediatric Immunology, University Hospital of Messina, Messina, Italy.